新生儿输注浓缩红细胞：对 FiO 和 PaO/SaO 比值的影响，以及对新生儿饱和度目标的影响。
Packed red blood cells transfusion in neonates: effect on FiO and PaO/SaO ratio, and implications for neonatal saturation targeting.
机构信息
Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.
The Faculty of Medicine of the Hebrew University, Jerusalem, Israel.
出版信息
J Perinatol. 2018 Jun;38(6):693-695. doi: 10.1038/s41372-018-0079-x. Epub 2018 Feb 21.
OBJECTIVE
To assess the effect of blood transfusions in neonates on partial pressure of oxygen in arterial blood (PaO), arterial hemoglobin oxygen saturation (SaO) and arterial hemoglobin oxygen saturation as measured by pulse oximetry (SpO).
STUDY DESIGN
Retrospective study of neonates that received a first blood transfusion while having an indwelling arterial line. We compared PaO, SaO SpO SaO/PaO ratio and fraction of inspired oxygen (FiO) 12 h before and after blood transfusion.
RESULTS
Post-transfusion neonates had higher PaO and SaO, had lower SaO/PaO ratio, and received higher FiO with no change in SpO.
CONCLUSIONS
Post-transfusion, neonates had lower hemoglobin oxygen affinity. They received higher FiO and had higher PaO at the same SpO. We speculate that FiO was increased in order to maintain SpO. Larger prospective trials are needed to confirm our findings.
目的
评估新生儿输血对动脉血氧分压（PaO）、动脉血氧饱和度（SaO）和脉搏血氧饱和度（SpO）测量的动脉血红蛋白氧饱和度的影响。
研究设计
对留置动脉导管的新生儿进行的回顾性研究。我们比较了输血前 12 小时和输血后的 PaO、SaO、SpO、SaO/PaO 比值和吸入氧分数（FiO）。
结果
输血后的新生儿 PaO 和 SaO 较高，SaO/PaO 比值较低，FiO 较高，SpO 无变化。
结论
输血后，新生儿血红蛋白氧亲和力降低。他们以相同的 SpO 接受更高的 FiO 和更高的 PaO。我们推测，为了维持 SpO，FiO 增加。需要更大的前瞻性试验来证实我们的发现。
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