伊朗伊斯法罕住院患者分离株中Ⅰ类、Ⅱ类和Ⅲ类整合子的调查
Investigation of Class I, II, and III Integrons Among Isolates from Hospitalized Patients in Isfahan, Iran.
作者信息
Halaji Mehrdad, Rezaei Aliakbar, Zalipoor Mehrdad, Faghri Jamshid
机构信息
Department of Microbiology, School of medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Oman Med J. 2018 Jan;33(1):37-42. doi: 10.5001/omj.2018.07.
Abstract
OBJECTIVES
This study aimed to determine the prevalence of class I, II, and III integrons among clinical isolates collected from hospitalized patients.
METHODS
This cross-sectional study was conducted at two teaching hospitals in Isfahan, Iran, from October 2015 to October 2016. A total of 147 non-duplicate isolates were collected from clinical specimens and identified as using standard microbiological methods and confirmed by genotyping. Antimicrobial susceptibility was determined using disc diffusion method, and the presence of integron genes was performed using the polymerase chain reaction.
RESULTS
Out of 147 confirmed isolates, 97.3% of isolates were extensive drug-resistant (XDR) and 2.7% were multidrug-resistant (MDR). Class I and II integrons were detected in 63.9% and 78.2% of the , respectively. Class III integron was not detected in any of the isolates.
CONCLUSION
Our results show a high prevalence of classes I and II integrons which may play a key role in the acquisition of MDR and XDR phenotype among isolates in our region. Therefore, use of appropriate infection control in clinical settings and implementation of treatment strategies is necessary for our hospitals.
摘要
目的
本研究旨在确定从住院患者收集的临床分离株中I类、II类和III类整合子的流行情况。
方法
本横断面研究于2015年10月至2016年10月在伊朗伊斯法罕的两家教学医院进行。从临床标本中总共收集了147株非重复分离株，采用标准微生物学方法进行鉴定，并通过基因分型进行确认。采用纸片扩散法测定抗菌药物敏感性，采用聚合酶链反应检测整合子基因的存在情况。
结果
在147株已确认的分离株中，97.3%的分离株为广泛耐药（XDR），2.7%为多重耐药（MDR）。I类和II类整合子分别在63.9%和78.2%的分离株中被检测到。在任何分离株中均未检测到III类整合子。
结论
我们的结果显示I类和II类整合子的高流行率，这可能在我们地区分离株中获得MDR和XDR表型方面起关键作用。因此，我们的医院在临床环境中使用适当的感染控制措施并实施治疗策略是必要的。
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