Gebrie Alemu, Gnanasekaran Natesan, Menon Menakath, Sisay Mekonnen, Zegeye Abriham
Medical Biochemistry, Department of Biomedical Sciences, School of Medicine, Debre Markos University, Debre Markos, Ethiopia.
Medical Biochemistry, Department of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
SAGE Open Med. 2018 Feb 12;6:2050312118756663. doi: 10.1177/2050312118756663. eCollection 2018.
Hypertension and dyslipidemia are the two coexisting and synergizing major risk factors for cardiovascular diseases. The cellular constituents of blood affect the volume and viscosity of blood, thus playing a key role in regulating blood pressure. Overweight and obesity are key determinants of adverse metabolic changes including an increase in blood pressure. The aim of this study was to evaluate lipid profiles and hematological parameters in hypertensive patients at Debre Markos Referral Hospital, Northwest Ethiopia.
Laboratory-based cross-sectional study was conducted in 100 eligible hypertensive patients at the hospital. The required amount of blood was withdrawn from the patients by healthcare professionals for immediate automated laboratory analyses. Data were collected on socio-demographic factors, anthropometric measurements, blood pressure, lipid profiles, and hematological parameters.
The mean serum levels of triglyceride, total cholesterol, and low-density lipoprotein were significantly higher than their respective cut-off values in the hypertensive patients. Besides, 54%, 52%, 35%, and 11% of the hypertensive patients had abnormal low-density lipoprotein, total cholesterol, triglyceride, and high-density lipoprotein levels, respectively. Higher levels of low-density lipoprotein, hemoglobin, and red blood cell count were observed in the hypertensive patients whose blood pressure had been poorly controlled than the controlled ones ( < 0.05). Waist circumference had a significant positive association with the serum levels of total cholesterol and white blood cell count ( < 0.05).
Hypertensive patients had a high prevalence of lipid profile abnormalities and poorly controlled blood pressure which synergize in accelerating other cardiovascular diseases. Some hematological parameters such as red blood cell count are also increased as do the severity of hypertension.
高血压和血脂异常是心血管疾病中两种并存且相互作用的主要危险因素。血液中的细胞成分会影响血液的容量和黏度，从而在调节血压方面发挥关键作用。超重和肥胖是包括血压升高在内的不良代谢变化的关键决定因素。本研究的目的是评估埃塞俄比亚西北部德布雷马科斯转诊医院高血压患者的血脂谱和血液学参数。
在该医院对100名符合条件的高血压患者进行了基于实验室的横断面研究。医护人员从患者身上抽取所需血量，以便立即进行自动实验室分析。收集了社会人口统计学因素、人体测量数据、血压、血脂谱和血液学参数等数据。
高血压患者的甘油三酯、总胆固醇和低密度脂蛋白的平均血清水平显著高于各自的临界值。此外，分别有54%、52%、35%和11%的高血压患者低密度脂蛋白、总胆固醇、甘油三酯和高密度脂蛋白水平异常。血压控制不佳的高血压患者的低密度脂蛋白、血红蛋白和红细胞计数水平高于血压得到控制的患者（<0.05）。腰围与总胆固醇血清水平和白细胞计数呈显著正相关（<0.05）。
高血压患者血脂谱异常的患病率较高，血压控制不佳，这两者相互作用会加速其他心血管疾病的发生。一些血液学参数，如红细胞计数，也会随着高血压严重程度的增加而升高。
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