在美国一份临床猪样本中鉴定出具有大刺突基因缺失的猪流行性腹泻病毒变异株。
Identification of porcine epidemic diarrhea virus variant with a large spike gene deletion from a clinical swine sample in the United States.
作者信息
Zhang Jianqiang, Yim-Im Wannarat, Chen Qi, Zheng Ying, Schumacher Loni, Huang Haiyan, Gauger Phillip, Harmon Karen, Li Ganwu
机构信息
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, 1850 Christensen Drive, Ames, IA, 50011, USA.
出版信息
Virus Genes. 2018 Apr;54(2):323-327. doi: 10.1007/s11262-018-1542-7. Epub 2018 Feb 21.
Two genetically different porcine epidemic diarrhea virus (PEDV) strains have been identified in the USA: US prototype (also called non-S INDEL) and S INDEL PEDVs. In February 2017, a PEDV variant (USA/OK10240-8/2017) was identified in a rectal swab from a sow farm in Oklahoma, USA. Complete genome sequence analyses indicated this PEDV variant was genetically similar to US non-S INDEL strain but had a continuous 600-nt (200-aa) deletion in the N-terminal domain of the spike gene compared to non-S INDEL PEDVs. This is the first report of detecting PEDV bearing large spike gene deletion in clinical swine samples in the USA.
在美国已鉴定出两种基因不同的猪流行性腹泻病毒（PEDV）毒株：美国原型毒株（也称为非S插入缺失毒株）和S插入缺失型PEDV毒株。2017年2月，在美国俄克拉何马州一个母猪场的直肠拭子中鉴定出一种PEDV变异株（USA/OK10240 - 8/2017）。全基因组序列分析表明，这种PEDV变异株在基因上与美国非S插入缺失毒株相似，但与非S插入缺失型PEDV毒株相比，其刺突基因的N端结构域有一个连续600个核苷酸（200个氨基酸）的缺失。这是美国首次在临床猪样本中检测到携带大刺突基因缺失的PEDV的报告。
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