在家猪中发现的具有刺突基因大片段缺失的新型猪流行性腹泻病毒变种。
New porcine epidemic diarrhoea virus variant with a large deletion in the spike gene identified in domestic pigs.
作者信息
Masuda Tsuneyuki, Murakami Satoshi, Takahashi Osamu, Miyazaki Ayako, Ohashi Seiichi, Yamasato Hiroshi, Suzuki Tohru
机构信息
Kurayoshi Livestock Hygiene Service Center, Kurayoshi, Tottori, Japan.
Life Technologies Japan Ltd., Thermo Fisher Scientific, Tokyo, Japan.
出版信息
Arch Virol. 2015 Oct;160(10):2565-8. doi: 10.1007/s00705-015-2522-z. Epub 2015 Jul 11.
From October 2013 to date, approximately 1,000 outbreaks of porcine epidemic diarrhoea virus (PEDV) have occurred in Japan. Porcine epidemic diarrhoea with non-lethal effects in piglets was identified in Tottori prefecture in October 2014. Complete genome analysis revealed that the causative pathogen, Tottori2, is a new PEDV variant with a large (582 nt) deletion in the spike gene. Phylogenetic analysis indicated that the Tottori2 PEDV strain might have been derived from the current PEDV strains circulating in domestic pigs. Moreover, the Tottori2 PEDV strain was successfully isolated in Vero cells by serial passage.
从2013年10月至今，日本已发生约1000起猪流行性腹泻病毒（PEDV）疫情。2014年10月，在鸟取县发现了对仔猪无致命影响的猪流行性腹泻。全基因组分析显示，致病病原体鸟取2型是一种新的PEDV变种，其刺突基因有一个大的（582个核苷酸）缺失。系统发育分析表明，鸟取2型PEDV毒株可能源自目前在家猪中流行的PEDV毒株。此外，通过连续传代，鸟取2型PEDV毒株在Vero细胞中成功分离出来。
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