MIIT Key Laboratory of Advanced Structural-Functional Integration Materials and Green Manufacturing Technology, Harbin Institute of Technology, Harbin, 150001, P. R. China.
School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001, P. R. China.
Small. 2018 Apr;14(14):e1703789. doi: 10.1002/smll.201703789. Epub 2018 Feb 22.
Near-infrared light-mediated theranostic agents with superior tissue penetration and minimal invasion have captivated researchers in cancer research in the past decade. Herein, a probe sonication-assisted liquid exfoliation approach for scalable and continual synthesis of colloidal rhenium disulfide nanosheets, which is further explored as theranostic agents for cancer diagnosis and therapy, is reported. Due to high-Z element of Re (Z = 75) and significant photoacoustic effect, the obtained PVP-capped ReS nanosheets are evaluated as bimodality contrast agents for computed tomography and photoacoustic imaging. In addition, utilizing the strong near-infrared absorption and ultrahigh photothermal conversion efficiency (79.2%), ReS nanosheets could also serve as therapeutic agents for photothermal ablation of tumors with a tumor elimination rate up to 100%. Importantly, ReS nanosheets show no obvious toxicity based on the cytotoxicity assay, serum biochemistry, and histological analysis. This work highlights the potentials of ReS nanosheets as a single-component theranostic nanoplatform for bioimaging and antitumor therapy.
近红外光介导的治疗剂具有优异的组织穿透性和最小的侵入性，在过去十年中吸引了癌症研究领域的研究人员。在此，报道了一种探针超声辅助液相剥离方法，用于可扩展和连续合成胶体二硫化铼纳米片，进一步将其探索为癌症诊断和治疗的治疗剂。由于 Re（Z = 75）的高 Z 元素和显著的光声效应，所得的 PVP 包覆的 ReS 纳米片被评估为计算机断层扫描和光声成像的双模式对比剂。此外，利用强近红外吸收和超高光热转换效率（79.2%），ReS 纳米片也可用作肿瘤光热消融的治疗剂，肿瘤消除率高达 100%。重要的是，根据细胞毒性测定、血清生化和组织学分析，ReS 纳米片没有明显的毒性。这项工作突出了 ReS 纳米片作为一种用于生物成像和抗肿瘤治疗的单一成分治疗诊断纳米平台的潜力。
