Gracia-Cazaña T, Milagro A, Queipo F, Gilaberte Y
Department of Dermatology, Hospital de Barbastro, Huesca, Spain.
Dermatol Online J. 2017 Sep 19;23(9):13030/qt0572r5qp.
Actinic keratoses are cutaneous lesions that appear as the result of the proliferation of atypical keratinocytes. These lesions are considered pre-malignant and they can progress to squamous cell carcinoma. Ingenol mebutate has been approved as an effective treatment for AK on the face and trunk. We studied the local skin reactions to this therapy. Data about local skin reactions were collected in a series of 5 patients with photographic documentation, a visual analog scale, and a ranking of satisfaction of the patient. Moderate to severe reactions were reported in most of patients, but only one stopped treatment early. The short duration of treatment contributes to high adherence to the therapy.
光化性角化病是由非典型角质形成细胞增殖导致的皮肤病变。这些病变被认为是癌前病变，可能会发展为鳞状细胞癌。咪喹莫特已被批准作为治疗面部和躯干光化性角化病的有效药物。我们研究了这种疗法引起的局部皮肤反应。通过对5例患者进行一系列观察，收集有关局部皮肤反应的数据，包括摄影记录、视觉模拟评分以及患者满意度排名。大多数患者报告有中度至重度反应，但只有1例提前停止治疗。治疗时间短有助于提高患者对该疗法的依从性。
