Garg Taru, Marak Anita, Ahmed Riaz, Chander Ram, Jain Manjula
Department of Dermatology and STD, Lady Hardinge Medical College. New Delhi, India.
Dermatol Online J. 2017 Aug 15;23(8):13030/qt38f676n9.
Primary localized cutaneous amyloidosis refers to a group of disorders characterized by deposition of amyloid in the dermis without any systemic involvement. It comprises the following clinical types: macular, lichenoid, nodular, and biphasic. There are also rare variants such as amyloidosis cutis dyscromica and poikiloderma-like cutaneous amyloidosis. We report a case of primary cutaneous amyloidosis in a 17-year-old boy with unusual pigmentation of various patterns (reticulate and diffuse pigmentation with mottling and rippling at places) and hypopigmented atrophic macules. Our patient also had nail, oral, and mucosal pigmentation that have not been described. Amyloid deposits were shown histopathologically in both hyperpigmented and hypopigmented macules.
原发性局限性皮肤淀粉样变是指一组以淀粉样蛋白沉积于真皮而无任何系统性受累为特征的疾病。它包括以下临床类型：斑疹型、苔藓样型、结节型和双相型。也有罕见的变异型，如皮肤异色性淀粉样变和类皮肤异色病样皮肤淀粉样变。我们报告一例17岁男孩的原发性皮肤淀粉样变，其有各种不寻常的色素沉着模式（网状和弥漫性色素沉着，局部有斑点和波纹）以及色素减退性萎缩斑。我们的患者还存在未被描述过的指甲、口腔和黏膜色素沉着。组织病理学显示色素沉着过多和色素沉着过少的斑疹中均有淀粉样蛋白沉积。
