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阴阳 1 在宫颈癌中的表达及其与 E-钙黏蛋白表达和 HPV16 E6 的相关性。

Expression of Yin Yang 1 in cervical cancer and its correlation with E-cadherin expression and HPV16 E6.

机构信息

Center of Reproductive Medicine, the first Affiliated Hospital of Guangxi Medical University, Nanning, China.

Center of Reproductive Medicine, the Affiliated Hospital of Guilin Medical College, Guilin, China.

出版信息

PLoS One. 2018 Feb 22;13(2):e0193340. doi: 10.1371/journal.pone.0193340. eCollection 2018.

DOI:10.1371/journal.pone.0193340
PMID:29470526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5823405/
Abstract

The molecular mechanisms of normal cervical squamous epithelium advancing to cervical intraepithelial neoplasia (CIN) and eventually to cervical squamous cell carcinoma (CSCC) are largely unknown. This study explored abnormal expression of Yin Yang 1 (YY1) in cervical cancer and its correlation with the expression of E-cadherin and human papillomavirus (HPV) 16 E6. YY1, E-cadherin and HPV16 E6 expression were detected by immunohistochemistry in 90 cervical tissue specimens collected from 30 patients with hysteromyoma, 15 patients with CIN I, 15 patients with CIN II-III, and 30 patients with CSCC. The H-score method was employed to measure the expression of YY1, E-cadherin and HPV16 E6. Increased expression of YY1 and HPV16 E6, and the decreased expression levels of E-cadherin were strongly associated with malignant transformation of the cervical epithelium and the histological progression of CSCC. The expression of YY1 in cervical tissues was inversely correlated with E-cadherin expression, and positively correlated with HPV16 E6 expression. Expression of YY1 in CSCC tissues was not significantly correlated with tumor differentiation, but was significantly correlated with an advanced clinical stage of CSCC. These results suggest that up-regulation of YY1 is closely associated with the progression of CSCC, and YY1 may play an important role in the pathogenesis of cervical cancer by modulating the expression of E-cadherin and HPV16 E6.

摘要

正常宫颈鳞状上皮向宫颈上皮内瘤变（CIN），最终向宫颈鳞状细胞癌（CSCC）进展的分子机制在很大程度上尚不清楚。本研究探讨了 Yin Yang 1（YY1）在宫颈癌中的异常表达及其与 E-钙黏蛋白和人乳头瘤病毒（HPV）16 E6 的表达的相关性。采用免疫组织化学法检测 90 例子宫肌瘤患者（30 例）、CIN I 患者（15 例）、CIN II-III 患者（15 例）和 CSCC 患者（30 例）的宫颈组织标本中 YY1、E-钙黏蛋白和 HPV16 E6 的表达。采用 H 评分法测量 YY1、E-钙黏蛋白和 HPV16 E6 的表达。YY1 和 HPV16 E6 的高表达以及 E-钙黏蛋白的低表达与宫颈上皮的恶性转化和 CSCC 的组织学进展密切相关。YY1 在宫颈组织中的表达与 E-钙黏蛋白的表达呈负相关，与 HPV16 E6 的表达呈正相关。YY1 在 CSCC 组织中的表达与肿瘤分化程度无显著相关性，但与 CSCC 的晚期临床分期显著相关。这些结果表明，YY1 的上调与 CSCC 的进展密切相关，YY1 可能通过调节 E-钙黏蛋白和 HPV16 E6 的表达在宫颈癌的发病机制中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/d2ff770f9526/pone.0193340.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/7c3f2e7191a4/pone.0193340.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/9b44fd0a9913/pone.0193340.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/baae799de995/pone.0193340.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/c2c451ce3d27/pone.0193340.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/d6d60ea35bc6/pone.0193340.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/d2ff770f9526/pone.0193340.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/7c3f2e7191a4/pone.0193340.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/9b44fd0a9913/pone.0193340.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/baae799de995/pone.0193340.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/c2c451ce3d27/pone.0193340.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/d6d60ea35bc6/pone.0193340.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/5823405/d2ff770f9526/pone.0193340.g006.jpg

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