Department of Translational Research, Nofer Institute of Occupational Medicine, Lodz, Poland.
Department of Gynecological Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, China.
Cancer Control. 2021 Jan-Dec;28:10732748211001808. doi: 10.1177/10732748211001808.
Cervical cancer is a common female cancer. It is strongly associated with human papillomavirus (HPV) infection. However, HPV infection alone is not sufficient to induce cervical cancer because its development is dependent on the coexistence of several factors that enable the virus to overcome the host immune system. These include individual genetic background, environmental factors, or diet, including dietary selenium intake. Selenium is an essential trace element with antiviral properties and has been shown to exert antitumor effects. Surprisingly, the role of selenium in cervical cancer has not been studied as intensively as in other cancers. Here, we have summarized the existing experimental data on selenium and cervical cancer. It may be helpful in evaluating the role of this nutrient in treatment of the mentioned malignancy as well as in planning further studies in this area.
宫颈癌是一种常见的女性癌症，与人类乳头瘤病毒（HPV）感染密切相关。然而，HPV 感染本身并不足以引起宫颈癌，因为其发展取决于几种因素的共存，这些因素使病毒能够克服宿主的免疫系统。这些因素包括个体遗传背景、环境因素或饮食，包括膳食硒的摄入。硒是一种具有抗病毒特性的必需微量元素，已被证明具有抗肿瘤作用。令人惊讶的是，硒在宫颈癌中的作用尚未像在其他癌症中那样得到深入研究。在这里，我们总结了关于硒和宫颈癌的现有实验数据。这可能有助于评估这种营养素在治疗上述恶性肿瘤中的作用，并为该领域的进一步研究提供参考。
