Lebuisson D A, Leroy L, Rigal G
Presse Med. 1986 Sep 25;15(31):1556-8.
Senile macular degeneration is a frequent cause of blindness for which there is no satisfactory medical treatment. A double-blind trial comparing Ginkgo biloba extract with a placebo was conducted in 10 out-patients at the Hôpital Foch. Drug effectiveness was assessed on the results of fundoscopy and of measurements of visual acuity and visual field. In spite of the small population sample, a statistically significant improvement in long distance visual acuity was observed after treatment with Ginkgo biloba extract. The assumed pathogenesis of senile macular degeneration is discussed with emphasis on free oxygenated radicals.
老年性黄斑变性是导致失明的常见原因，目前尚无令人满意的医学治疗方法。在福煦医院对10名门诊患者进行了一项将银杏叶提取物与安慰剂进行对比的双盲试验。根据眼底镜检查结果以及视力和视野测量结果评估药物疗效。尽管样本量小，但在用银杏叶提取物治疗后，观察到远距离视力有统计学上的显著改善。文中讨论了老年性黄斑变性的假定发病机制，重点是游离氧自由基。
