Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia; St Vincent's Clinical School, UNSW Darlinghurst, NSW 2010, Australia.
EMBL Australia Node in Single Molecule Science, School of Medical Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.
Int J Biochem Cell Biol. 2018 Apr;97:104-107. doi: 10.1016/j.biocel.2018.02.011. Epub 2018 Feb 20.
The ability of cells to sense and respond to their physical environment is fundamental to a broad spectrum of biological processes. Cells express an array of force sensors that can transduce mechanical inputs into biochemical signals, including the mechanically activated ion channels PIEZO1, PIEZO2 and TRPV4. The identification and characterisation of mechanically activated ion channels has proven challenging, as has identifying their mode of activation and regulation in vivo. However, the diverse channelopathies associated with the known channels highlights their physiological importance.
细胞感知和响应其物理环境的能力是广泛的生物过程的基础。细胞表达了一系列力传感器，可将机械输入转化为生化信号，包括机械激活的离子通道 PIEZO1、PIEZO2 和 TRPV4。鉴定和表征机械激活的离子通道具有挑战性，因为鉴定它们在体内的激活和调节方式也具有挑战性。然而，与已知通道相关的多种通道病突出了它们的生理重要性。
