• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

丹参酮IIA抑制HNE-1鼻咽癌细胞增殖的体外研究

Tanshinone IIA suppress the proliferation of HNE-1 nasopharyngeal carcinoma an in vitro study.

作者信息

Zhou Mingguang, Zhou Guojin, Hu SunHong, Zhang Lei

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, Sir Sun Sun Shaw Hospital, School of Medicine, ZheJiang University, Hangzhou 310016, China.

出版信息

Saudi J Biol Sci. 2018 Feb;25(2):267-272. doi: 10.1016/j.sjbs.2016.11.004. Epub 2016 Nov 10.

DOI:10.1016/j.sjbs.2016.11.004
PMID:29472776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5815998/
Abstract

Nasopharyngeal carcinoma (NPC) at present is considered to be one of the fatal diseases detected commonly in the people belonging to Southeast Asia and southern China. According to the WHO reports among the detected cases of NPC worldwide, 80% are from China. The present study investigates the effect of tanshinone IIA on the migration and invasion potential of HNE-1NPC cells and studied the detailed mechanism involved. Effect of the tanshinone IIA on viability of the HNE-1NPC cells was analyzed by MTS assay. Cell matrigel invasion and wound-healing motility assays, respectively were used for the analysis of invasion and migration potential of HNE-1 cells. Tanshinone IIA inhibited the viability of HNE-1cells in a dose dependent manner. Migration and invasion potential of the tanshinone IIA treated cells was reduced significantly ( < 0.05) compared to the control cells after 48 h. Analysis of the proteins involved in migration and invasion revealed a significant decrease in the expression of matrix metalloproteinase (MMP)-2 and MMP-9 on treatment with tanshinone IIA. It also inhibited the p65 and p50 expression in the nuclear fractions of HNE-1 cells after 48 h. Thus, tanshinone IIA inhibits migration and invasion potential of the HNE-1NPC cells through reduction in the expression of matrix metalloproteinases. Therefore, tanshinone IIA can be used for the treatment of NPC.

摘要

鼻咽癌（NPC）目前被认为是在东南亚和中国南方人群中常见的致命疾病之一。根据世界卫生组织的报告，全球检测到的鼻咽癌病例中，80%来自中国。本研究调查了丹参酮IIA对HNE-1NPC细胞迁移和侵袭能力的影响，并研究了其中涉及的详细机制。通过MTS试验分析丹参酮IIA对HNE-1NPC细胞活力的影响。分别使用细胞基质胶侵袭试验和伤口愈合运动试验分析HNE-1细胞的侵袭和迁移能力。丹参酮IIA以剂量依赖性方式抑制HNE-1细胞的活力。与对照细胞相比，48小时后丹参酮IIA处理的细胞的迁移和侵袭能力显著降低（<0.05）。对参与迁移和侵袭的蛋白质分析显示，用丹参酮IIA处理后，基质金属蛋白酶（MMP）-2和MMP-9的表达显著降低。48小时后，它还抑制了HNE-1细胞核组分中p

65和p50的表达。因此，丹参酮IIA通过降低基质金属蛋白酶的表达来抑制HNE-1NPC细胞的迁移和侵袭能力。因此，丹参酮IIA可用于治疗鼻咽癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/ec922ca3a036/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/2af36f65b0bf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/69279d524b6d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/02f241badb42/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/d71034b3abcb/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/ec922ca3a036/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/2af36f65b0bf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/69279d524b6d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/02f241badb42/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/d71034b3abcb/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c192/5815998/ec922ca3a036/gr5.jpg

相似文献

1
Tanshinone IIA suppress the proliferation of HNE-1 nasopharyngeal carcinoma an in vitro study.丹参酮IIA抑制HNE-1鼻咽癌细胞增殖的体外研究
Saudi J Biol Sci. 2018 Feb;25(2):267-272. doi: 10.1016/j.sjbs.2016.11.004. Epub 2016 Nov 10.
2
Tanshinone IIA regulates microRNA‑125b/foxp3/caspase‑1 signaling and inhibits cell viability of nasopharyngeal carcinoma.丹参酮 IIA 通过调控 microRNA-125b/foxp3/caspase-1 信号通路抑制鼻咽癌细胞活力。
Mol Med Rep. 2021 May;23(5). doi: 10.3892/mmr.2021.12010. Epub 2021 Mar 24.
3
High-Dose Tanshinone IIA Suppresses Migration and Proliferation While Promoting Apoptosis of Astrocytoma Cells Via Notch-1 Pathway.高剂量丹参酮 IIA 通过 Notch-1 通路抑制星形细胞瘤细胞迁移和增殖并促进其凋亡。
Neurochem Res. 2018 Sep;43(9):1855-1861. doi: 10.1007/s11064-018-2601-0. Epub 2018 Jul 31.
4
Tanshinone IIA decreases the migratory ability of AGS cells by decreasing the protein expression of matrix metalloproteinases, nuclear factor κB-p65 and cyclooxygenase-2.丹参酮 IIA 通过降低基质金属蛋白酶、核因子 κB-p65 和环氧化酶-2 的蛋白表达来降低 AGS 细胞的迁移能力。
Mol Med Rep. 2016 Feb;13(2):1263-8. doi: 10.3892/mmr.2015.4658. Epub 2015 Dec 8.
5
Evodiamine inhibits the migration and invasion of nasopharyngeal carcinoma cells in vitro via repressing MMP-2 expression.吴茱萸碱通过抑制MMP-2表达在体外抑制鼻咽癌细胞的迁移和侵袭。
Cancer Chemother Pharmacol. 2015 Dec;76(6):1173-84. doi: 10.1007/s00280-015-2902-9. Epub 2015 Nov 6.
6
Tanshinone IIA Inhibits Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Modulation of STAT3-CCL2 Signaling.丹参酮IIA通过调节STAT3-CCL2信号通路抑制膀胱癌细胞的上皮-间质转化
Int J Mol Sci. 2017 Jul 25;18(8):1616. doi: 10.3390/ijms18081616.
7
Tanshinone IIA combined with adriamycin inhibited malignant biological behaviors of NSCLC A549 cell line in a synergistic way.丹参酮IIA联合阿霉素以协同方式抑制非小细胞肺癌A549细胞系的恶性生物学行为。
BMC Cancer. 2016 Nov 18;16(1):899. doi: 10.1186/s12885-016-2921-x.
8
Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity.丹参酮 IIA 通过抑制 YAP 转录活性抑制宫颈癌干细胞的迁移和侵袭。
Biomed Pharmacother. 2018 Sep;105:758-765. doi: 10.1016/j.biopha.2018.06.028. Epub 2018 Jun 14.
9
Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53-cyclin B1/CDC2.丹参酮IIA通过p53-细胞周期蛋白B1/细胞分裂周期蛋白2抑制人鼻咽癌细胞的增殖并诱导其凋亡。
Oncol Lett. 2019 Sep;18(3):3317-3322. doi: 10.3892/ol.2019.10658. Epub 2019 Jul 24.
10
Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro.丹参酮 IIA 诱导骨肉瘤 MG-63 细胞系凋亡并抑制其体外增殖、迁移和侵袭。
Anticancer Drugs. 2012 Feb;23(2):212-9. doi: 10.1097/CAD.0b013e32834e5592.

引用本文的文献

1
Natural products targeting ferroptosis pathways in cancer therapy (Review).天然产物靶向癌症治疗中的铁死亡途径（综述）。
Oncol Rep. 2024 Sep;52(3). doi: 10.3892/or.2024.8782. Epub 2024 Jul 26.
2
Recent Research Progress (2015-2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA.丹参酮IIA药理作用及机制的近期研究进展（2015 - 2021年）与展望
Front Pharmacol. 2021 Nov 8;12:778847. doi: 10.3389/fphar.2021.778847. eCollection 2021.
3
The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients.

本文引用的文献

1
Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway.黄芩素通过下调 ERK 通路抑制肝癌细胞的侵袭和转移能力。
PLoS One. 2013 Sep 6;8(9):e72927. doi: 10.1371/journal.pone.0072927. eCollection 2013.
2
Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity.去甲斑蝥素通过调节 NF-κB 活性转录抑制 MMP-9 表达对肝癌的抗转移作用。
PLoS One. 2012;7(2):e31055. doi: 10.1371/journal.pone.0031055. Epub 2012 Feb 7.
3
Tanshinone IIA inhibits BT-20 human breast cancer cell proliferation through increasing caspase 12, GADD153 and phospho-p38 protein expression.
丹参酮的抗癌特性及其活性成分的药理作用。
Front Pharmacol. 2020 Mar 19;11:193. doi: 10.3389/fphar.2020.00193. eCollection 2020.
4
Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells via the PI3K/Akt/ERK signaling pathway.丹参酮IIA通过PI3K/Akt/ERK信号通路逆转表皮生长因子（EGF）和转化生长因子-β1（TGF-β1）介导的HepG2细胞上皮-间质转化。
Oncol Lett. 2019 Dec;18(6):6554-6562. doi: 10.3892/ol.2019.11032. Epub 2019 Nov 1.
丹参酮 IIA 通过增加半胱天冬酶 12、GADD153 和磷酸化 p38 蛋白的表达抑制 BT-20 人乳腺癌细胞增殖。
Int J Mol Med. 2012 May;29(5):855-63. doi: 10.3892/ijmm.2012.908. Epub 2012 Feb 7.
4
Matrine inhibits matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells.苦参碱抑制人肝癌细胞基质金属蛋白酶-9的表达及侵袭。
J Asian Nat Prod Res. 2011 Mar;13(3):242-50. doi: 10.1080/10286020.2010.551641.
5
Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells.uPAR 和 MMP-9 在脂筏中的定位对于人乳腺癌细胞的迁移、侵袭和血管生成至关重要。
BMC Cancer. 2010 Nov 24;10:647. doi: 10.1186/1471-2407-10-647.
6
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting.基质金属蛋白酶在癌症进展中的作用及其药理学靶向。
FEBS J. 2011 Jan;278(1):16-27. doi: 10.1111/j.1742-4658.2010.07919.x. Epub 2010 Nov 19.
7
Tanshinone IIA inhibits Hep-J5 cells by increasing calreticulin, caspase 12 and GADD153 protein expression.丹参酮 IIA 通过增加钙网织蛋白、半胱天冬酶 12 和 GADD153 蛋白的表达来抑制 Hep-J5 细胞。
Int J Mol Med. 2010 Sep;26(3):379-85.
8
Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential.丹参酮 IIA 通过诱导活性氧和降低线粒体膜电位诱导人肺癌 A549 细胞凋亡。
Int J Mol Med. 2010 Feb;25(2):231-6.
9
Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling.苦参碱通过 VEGF-Akt-NF-κB 信号通路抑制乳腺癌细胞的增殖和侵袭。
Cytotechnology. 2009 Apr;59(3):219-29. doi: 10.1007/s10616-009-9225-9. Epub 2009 Sep 17.
10
Tanshinone IIA down-regulates the protein expression of ErbB-2 and up-regulates TNF-alpha in colon cancer cells in vitro and in vivo.丹参酮IIA在体外和体内均可下调结肠癌细胞中ErbB-2的蛋白表达并上调肿瘤坏死因子-α（TNF-α）。
Int J Mol Med. 2008 Dec;22(6):847-51.