Fu Li, Han Bing, Zhou Yang, Ren Jie, Cao Wenzhi, Patel Gopal, Kai Guoyin, Zhang Jun
School of Life Sciences, Institute of Plant Biotechnology, Shanghai Normal University, Shanghai, China.
Laboratory of Medicinal Plant Biotechnology, College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Front Pharmacol. 2020 Mar 19;11:193. doi: 10.3389/fphar.2020.00193. eCollection 2020.
Cancer is a common malignant disease worldwide with an increasing mortality in recent years. , a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of years. The liposoluble tanshinones in are important bioactive components and mainly include tanshinone IIA, dihydrodanshinone, tanshinone I, and cryptotanshinone. Previous studies showed that these four tanshinones exhibited distinct inhibitory effects on tumor cells through different molecular mechanisms and . The mechanisms mainly include the inhibition of tumor cell growth, metastasis, invasion, and angiogenesis, apoptosis induction, cell autophagy, and antitumor immunity, and so on. In this review, we describe the latest progress on the antitumor functions and mechanisms of these four tanshinones to provide a deeper understanding of the efficacy. In addition, the important role of tumor immunology is also reviewed.
癌症是一种在全球范围内常见的恶性疾病，近年来死亡率不断上升。丹参，一种著名的传统中药，已被用于治疗心脑血管疾病数千年。丹参中的脂溶性丹参酮是重要的生物活性成分，主要包括丹参酮IIA、二氢丹参酮、丹参酮I和隐丹参酮。先前的研究表明，这四种丹参酮通过不同的分子机制对肿瘤细胞表现出明显的抑制作用。其机制主要包括抑制肿瘤细胞生长、转移、侵袭和血管生成、诱导细胞凋亡、细胞自噬以及抗肿瘤免疫等。在本综述中，我们描述了这四种丹参酮抗肿瘤功能和机制的最新进展，以更深入地了解其疗效。此外，还综述了肿瘤免疫学的重要作用。
