Wang Fei, Wang Minji
College of Acupuncture-Moxibustion and Massage of Henan University of CM, Zhengzhou 450008, China.
Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Henan University of CM, Zhengzhou 450003.
Zhongguo Zhen Jiu. 2018 Feb 12;38(2):127-34. doi: 10.13703/j.0255-2930.2018.02.004.
To observe the effects for vascular dementia (VD) of kidney essence deficiency among acupuncture at five mind points combined with modified kidney decoction, simple acupuncture at five mind points and simple modified kidney decoction.
A total of 180 VD patients were randomly assigned into a combination group, an acupuncture group and a herb group, 60 cases in each one. The conventional western medication and rehabilitation training were for all the patients. The modified kidney decoction was used in the herb group; acupuncture at Baihui (GV 20) and Sishencong (EX-HN 1) was applied in the acupuncture group; the above two methods were for the cases in the combination group. Acupuncture was used for 7 courses, twice a day, and 5 days as a course. The hasegawa dementia scale (HDS), the brief screening scale for dementia (BSSD) and the mini-mental state examination (MMSE) were applied before and after treatment. The serum superoxide dismutase (SOD), calcitonin gene-related peptide (CGRP) and lipid peroxidation (LPO) were detected before and after treatment. The effects were evaluated.
The total effective rate of the combination group was 91.7% (55/60), which was better than 68.3% (41/60) in the herb group and 78.3% (47/60) in the acupuncture group (both <0.05). After treatment, the scores of HDS, BSSD and MMSE were higher than those before treatment in the three groups (all <0.05), and the scores in the combination group were superior to those in the other two groups (all <0.05). SOD and CGRP increased and LPO decreased after treatment in the three groups (all <0.05), and the results in the combination group were better (all <0.05). .
Acupuncture at five mind points combined with modified kidney decoction for VD is better than simple five mind acupuncture and simple modified kidney decoction.
观察针刺五神穴配合加味地黄饮子、单纯针刺五神穴及单纯加味地黄饮子对肾精亏虚型血管性痴呆（VD）的影响。
将180例VD患者随机分为联合组、针刺组和中药组，每组60例。所有患者均给予西医常规药物及康复训练。中药组采用加味地黄饮子；针刺组针刺百会（GV 20）、四神聪（EX-HN 1）；联合组采用上述两种方法。针刺7个疗程，每日2次，5日为1个疗程。治疗前后采用长谷川痴呆量表（HDS）、简易精神状态检查表（BSSD）及简易精神状态检查量表（MMSE）进行评定。检测治疗前后血清超氧化物歧化酶（SOD）、降钙素基因相关肽（CGRP）及脂质过氧化产物（LPO）水平，并进行疗效评价。
联合组总有效率为91.7%（55/60），优于中药组的68.3%（41/60）和针刺组的78.3%（47/60）（均P<0.05）。治疗后，三组HDS、BSSD及MMSE评分均高于治疗前（均P<0.05），且联合组评分优于其他两组（均P<0.05）。三组治疗后SOD、CGRP升高，LPO降低（均P<0.05），联合组改善情况更佳（均P<0.05）。
针刺五神穴配合加味地黄饮子治疗VD疗效优于单纯针刺五神穴及单纯加味地黄饮子。
