Leng Yunxia, Tam Emily K, Falavarjani Khalil Ghasemi, Tsui Irena
Ophthalmic Surg Lasers Imaging Retina. 2018 Dec 1;49(12):925-931. doi: 10.3928/23258160-20181203-03.
To investigate the effect of age and refractive error on changes in the retinal microvascular network.
Subjects were recruited from the Doheny Eye Institute. Refractive error and axial length were measured. High myopia was defined as refractive error greater than -6 diopters (D). Optical coherence tomography angiography (OCTA) imaging was performed and images were analyzed using fractal analysis. Primary outcomes were superficial capillary plexus (SCP) vessel density, deep capillary plexus (DCP) vessel density, and foveal avascular zone (FAZ) area.
One hundred thirty-eight eyes of 69 subjects were included. Twenty-eight (41%) subjects were male and 41 (59%) subjects were female. Mean age was 42.81 years ± 19.91 years (range: 8 years to 87 years). Mean refractive error was -1.74 D ± 3.18 D (range: -15.78 D to 4.25 D), and mean axial length (AL) was 24.29 mm ± 1.35 mm (range: 21.73 mm to 28.32 mm). SCP and DCP vessel densities were negatively correlated to age (r = -0.22, P = .011; and r = -0.49, P < .001). Controlling for age, patients with high myopia and longer AL had decreased SCP density (P = .021 and P = .027, respectively), but no difference in DCP vessel density was observed (P = .065 and P = .058, respectively). FAZ area was not significantly correlated to age, gender, refraction, or AL.
SCP and DCP vessel densities decreased with age. In addition, SCP density but not DCP vessel density was reduced in eyes with high myopia and longer AL. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:925-931.].
探讨年龄和屈光不正对视网膜微血管网络变化的影响。
受试者来自多希尼眼科研究所。测量屈光不正和眼轴长度。高度近视定义为屈光不正大于-6屈光度（D）。进行光学相干断层扫描血管造影（OCTA）成像，并使用分形分析对图像进行分析。主要观察指标为浅表毛细血管丛（SCP）血管密度、深部毛细血管丛（DCP）血管密度和黄斑无血管区（FAZ）面积。
纳入69名受试者的138只眼。28名（41%）受试者为男性，41名（59%）受试者为女性。平均年龄为42.81岁±19.91岁（范围：8岁至87岁）。平均屈光不正为-1.74 D±3.18 D（范围：-15.78 D至4.25 D），平均眼轴长度（AL）为24.29 mm±1.35 mm（范围：21.73 mm至28.32 mm）。SCP和DCP血管密度与年龄呈负相关（r = -0.22，P = 0.011；r = -0.49，P < 0.001）。在控制年龄后，高度近视且眼轴较长的患者SCP密度降低（分别为P = 0.021和P = 0.027），但未观察到DCP血管密度有差异（分别为P = 0.065和P = 0.058）。FAZ面积与年龄、性别、屈光或眼轴无显著相关性。
SCP和DCP血管密度随年龄降低。此外，高度近视且眼轴较长的眼中SCP密度降低，但DCP血管密度未降低。[《眼科手术、激光与视网膜成像》。2018；49：925 - 931。]
