Hoxhaj Pranvera, Habiya Sana K, Sayabugari Rithika, Balaji Roghan, Xavier Roshni, Ahmad Arghal, Khanam Mousumi, Kachhadia Meet Popatbhai, Patel Tirath, Abdin Zain U, Haider Ali, Nazir Zahra
Medicine, University of Medicine, Tirana, Tirana, ALB.
Obstetrics and Gynaecology, Scher & Kerenyi MDS, New York, USA.
Cureus. 2023 Jun 30;15(6):e41223. doi: 10.7759/cureus.41223. eCollection 2023 Jun.
It has been noted that people who have epilepsy have an increased propensity for cognitive dysfunction. We explored 25 relevant articles on PubMed and Cochrane Library after implementing inclusion criteria. Different factors have been postulated and studied that may cause cognitive dysfunction in these patients; structural brain abnormalities, polypharmacy of antiepileptic medication, and neuropsychiatric disorders are the most common causes. Cognitive assessments such as Montreal Cognitive Assessment (MOCA) and Mini-Mental State Exam (MMSE) are the mainstay tools used to diagnose the degree of cognitive decline, and alterations in EEG (electroencephalogram) parameters have also been noted in people with cognitive decline. The mechanisms and treatments for cognitive decline are still being studied, while attention has also been directed toward preventive and predictive methods. Early detection and treatment of cognitive impairment can help minimize its impact on the patient's quality of life. Regular cognitive assessments are essential for epileptic patients, particularly those on multiple antiepileptic drugs. While proper management of epilepsy and related comorbidities would reduce cognitive decline and improve the overall quality of life for people with epilepsy.
人们已经注意到,癫痫患者出现认知功能障碍的倾向增加。我们在实施纳入标准后,在PubMed和Cochrane图书馆中检索了25篇相关文章。已经提出并研究了不同的因素,这些因素可能导致这些患者出现认知功能障碍;脑结构异常、抗癫痫药物的联合使用以及神经精神障碍是最常见的原因。诸如蒙特利尔认知评估(MOCA)和简易精神状态检查(MMSE)等认知评估是用于诊断认知衰退程度的主要工具,并且在认知衰退的人群中也已注意到脑电图(EEG)参数的改变。认知衰退的机制和治疗方法仍在研究中,同时注意力也已转向预防和预测方法。早期发现和治疗认知障碍有助于将其对患者生活质量的影响降至最低。定期进行认知评估对癫痫患者至关重要,尤其是那些服用多种抗癫痫药物的患者。而对癫痫及相关合并症的妥善管理将减少认知衰退,并改善癫痫患者的整体生活质量。