Kraus H, Schuhmann R
Acta Cytol. 1979 Mar-Apr;23(2):114-8.
In 40 women who had received radiotherapy for gynecologic carcinoma, biopsy was performed because recurrence of the tumor was clinically and/or cytologically suspected. Malignant tissue was found in two-thirds of the biopsy specimens. All the cytologic smears that preceded the biopsies were rescrutinized in order to establish criteria for recurrence of tumor. The initial indication of recurrence of squamous cell carcinoma was small cells with extremely dark, hyperchromatic nuclei. The nuclei were, as a rule, elongated, and their maximum diameter was about 8 micrometers. In the first smears these cells lay singly; later they were shed in clusters. The typical larger polymorphic cells without irradiation changes appeared later. Recurrence of adenocarcinoma was first indicated by more or less polymorphic, mainly ovoid naked nuclei about 20 micrometers in diameter with prominent nucleoli. The diagnosis of recurrent adenocarcinoma is often difficult since nuclear hyperchromasia may be absent in the early smears.
在40名接受过妇科癌症放射治疗的女性中，由于临床和/或细胞学上怀疑肿瘤复发而进行了活检。在三分之二的活检标本中发现了恶性组织。对所有活检前的细胞学涂片进行了重新检查，以确定肿瘤复发的标准。鳞状细胞癌复发的最初迹象是细胞核极其深染、核染色质增多的小细胞。通常，细胞核呈细长形，其最大直径约为8微米。在最初的涂片中，这些细胞单个存在；后来它们成簇脱落。典型的未发生放射改变的较大多形性细胞出现较晚。腺癌复发首先表现为或多或少呈多形性、主要为直径约20微米的卵圆形裸核，核仁突出。复发性腺癌的诊断往往很困难，因为早期涂片中可能没有核染色质增多的情况。
