Matsuyama S, Tokunaga T, Mimori H, Koyama N, Kuwahara S, Inoue S, Itoh M, Fujisaki S, Maeyama M
Nihon Sanka Fujinka Gakkai Zasshi. 1985 Jul;37(7):1125-34.
Nine cases of mixed mesodermal tumor of the uterus were reviewed cytologically. Abnormal cytologic findings were seen in all cases, but malignant cells were detected in only 17 of 30 cytologic smears sampled prior to the therapy (2 of 7 pool smears, 2 of 3 portio rubbing-smears, 6 of 8 endocervical smears and 7 of 12 tumor-rubbing smears). The most commonly encountered cellular components were epithelial malignant cells which showed a close resemblance to those derived from uterine carcinomas, but tended to have multiple nuclei. In other cytologic components, a rhabdomyosarcoma was characterized by large, isolated, round or strap-shaped malignant cells with granular cytoplasms, bizarre and eccentric nuclei and one or more prominent nucleoli. Another infrequent cellular component was a fibrogenic sarcomatous cell which had an illdefined lacy cytoplasm and single or multiple nuclei containing rather finely granular chromatin, and occasionally formed a cluster. In several cytologic specimens, there were also seen multinucleated giant cells which were not in keeping with their histologic origins.
对9例子宫混合性中胚层肿瘤进行了细胞学检查。所有病例均有异常细胞学表现，但在治疗前采集的30份细胞学涂片样本中，仅在17份中检测到恶性细胞（7份混合涂片中有2份，3份宫颈阴道部擦片中有2份，8份宫颈管涂片中有6份，12份肿瘤擦片中有7份）。最常见的细胞成分是上皮性恶性细胞，它们与子宫癌来源的细胞非常相似，但往往有多个细胞核。在其他细胞学成分中，横纹肌肉瘤的特征是大的、孤立的、圆形或带状的恶性细胞，细胞质呈颗粒状，核怪异且偏心，有一个或多个明显的核仁。另一种不常见的细胞成分是纤维肉瘤细胞，其细胞质呈模糊的花边状，有单个或多个细胞核，染色质相当细颗粒状，偶尔形成簇。在几个细胞学标本中，还可见到与组织学来源不符的多核巨细胞。
