环状 RNA GRB10 作为竞争性内源性 RNA 调节退行性椎间盘核髓核细胞死亡。

Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk.

机构信息

Department of Orthopaedics, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine (Cangzhou No.2 Hospital), 31 Huanghe Road, Hebei, 061001, Cangzhou, China.

Department of Orthopaedics, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, 300052, Tianjin, China.

出版信息

Cell Death Dis. 2018 Feb 23;9(3):319. doi: 10.1038/s41419-017-0232-z.

Intervertebral disc degeneration (IDD) is an important factor leading to low back pain, but the underlying mechanisms remain poorly understood. Compared with normal nucleus pulposus (NP) tissues, the expression of circ-GRB10 was downregulated in IDD. Furthermore, overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. In conclusion, the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD.