环状 RNA 的生物发生。
Biogenesis of Circular RNAs.
机构信息
Institut de biologie moléculaire et cellulaire du CNRS, Architecture et Réactivité de l'ARN, 67 084 Strasbourg, France.
出版信息
Cell. 2014 Sep 25;159(1):13-14. doi: 10.1016/j.cell.2014.09.005.
PMID:25259915
Abstract
Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al. show that exon circularization depends on flanking intronic complementary sequences. Both papers show that several types of circular RNA transcripts can be produced from a single gene.
摘要
环状 RNA 通过多种机制在剪接过程中产生。Ashwal-Fluss 等人证明，外显子环化和线性剪接以组织特异性的方式相互竞争，而 Zhang 等人则表明外显子环化依赖于侧翼内含子互补序列。这两篇论文都表明，单个基因可以产生几种类型的环状 RNA 转录本。
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