South African Research Chairs Initiative (SARChI), PTSD Program, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Faculdade de Ciências Médicas e da Saúde, Universidade Federal da Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
AIDS Behav. 2018 Oct;22(10):3155-3165. doi: 10.1007/s10461-018-2072-y.
Depression and trauma are common among women living with HIV. This is the first study to track the longitudinal course of depression and examine the relationship between depression and trauma over time among women in South Africa. HIV-infected and uninfected women (N = 148) were assessed at baseline and one year later. Results of a path analysis show the multi-directional and entwined influence of early life stress, other life-threatening traumas across the lifespan, depression and PTSD over the course of HIV. We also observed higher rates of depressive symptomatology and more persistent cases among infected women compared to uninfected women, as well as a more consistent and enduring relationship between childhood trauma and depression among women living with HIV. The present study is unique in documenting the course of untreated depression and PTSD in women with and without HIV infection with a high prevalence of early childhood trauma.
抑郁和创伤在感染艾滋病毒的女性中很常见。这是第一项跟踪抑郁纵向病程的研究，并在南非女性中检查了抑郁和创伤随时间的关系。在基线和一年后评估了感染艾滋病毒和未感染艾滋病毒的女性（N=148）。路径分析的结果表明，早期生活压力、一生中其他危及生命的创伤、抑郁和创伤后应激障碍在艾滋病毒过程中存在多向和交织的影响。我们还观察到，与未感染艾滋病毒的女性相比，感染艾滋病毒的女性中抑郁症状的发生率更高，且更持久，而在感染艾滋病毒的女性中，童年创伤与抑郁之间的关系更一致且更持久。本研究的独特之处在于记录了患有和未患有艾滋病毒感染的女性未经治疗的抑郁和创伤后应激障碍的病程，且这些女性有很高的童年早期创伤发生率。
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