Universidade Federal do Mato Grosso do Sul, Faculdade de Medicina, Campo Grande, MS, Brazil.
Universidade Federal do Mato Grosso do Sul, Faculdade de Medicina, Campo Grande, MS, Brazil.
Braz J Infect Dis. 2018 Mar-Apr;22(2):142-145. doi: 10.1016/j.bjid.2018.01.003. Epub 2018 Feb 21.
The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Production of IL-6, IL-10, TNF-α, IFN-γ, and IL-17 was detected; in contrast IL-4 was identified. Host-related factors could help explain such a level of infection control, namely the differentiated modulation of the cellular immune response and a non-polarized cytokine response of the TH1 and TH2 profiles.
HIV-1 初始病毒感染可能表现出不同的临床和实验室过程，并导致快速、中期或长期进展。在非进展者中，精英控制器是指在没有抗逆转录病毒治疗（ART）的情况下，能够最有效地控制感染的人群。本文描述了 TH1、TH2 和 TH17 细胞因子谱，以及一名 HIV 感染者在未接受抗逆转录病毒治疗时病毒载量不可检测的临床和实验室方面。检测到了 IL-6、IL-10、TNF-α、IFN-γ 和 IL-17 的产生；相反，IL-4 被鉴定出来。宿主相关因素可以帮助解释这种感染控制水平，即细胞免疫反应的分化调节和 TH1 和 TH2 谱的非极化细胞因子反应。
