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使用周的通用伪氨基酸组成方法来分析受体相关蛋白（RAP）与蛋白质结构域各种折叠模式之间的进化关系。

Using Chou's general PseAAC to analyze the evolutionary relationship of receptor associated proteins (RAP) with various folding patterns of protein domains.

作者信息

Muthu Krishnan S

机构信息

MTCC, Institute of Microbial Technology (CSIR-IMTECH), Sector-39A, Chandigarh, India.

出版信息

J Theor Biol. 2018 May 14;445:62-74. doi: 10.1016/j.jtbi.2018.02.008. Epub 2018 Feb 22.

DOI:10.1016/j.jtbi.2018.02.008
PMID:29476832
Abstract

The receptor-associated protein (RAP) is an inhibitor of endocytic receptors that belong to the lipoprotein receptor gene family. In this study, a computational approach was tried to find the evolutionarily related fold of the RAP proteins. Through the structural and sequence-based analysis, found various protein folds that are very close to the RAP folds. Remote homolog datasets were used potentially to develop a different support vector machine (SVM) methods to recognize the homologous RAP fold. This study helps in understanding the relationship of RAP homologs folds based on the structure, function and evolutionary history.

摘要

受体相关蛋白（RAP）是脂蛋白受体基因家族中内吞受体的一种抑制剂。在本研究中，尝试采用一种计算方法来寻找与RAP蛋白进化相关的折叠结构。通过基于结构和序列的分析，发现了各种与RAP折叠结构非常相似的蛋白质折叠结构。利用远程同源数据集有可能开发出不同的支持向量机（SVM）方法来识别同源的RAP折叠结构。这项研究有助于基于结构、功能和进化历史来理解RAP同源物折叠结构之间的关系。

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