1型糖尿病伴或不伴增殖性视网膜病变患者中可溶性免疫复合物、胰岛素抗体及胰岛素-抗胰岛素复合物与血小板及凝血因子的关系。
The relationship of soluble immune complexes, insulin antibodies and insulin-anti-insulin complexes to platelet and coagulation factors in type 1 diabetic patients with and without proliferative retinopathy.
作者信息
Di Mario U, Borsey D Q, Contreas G, Prowse C V, Clarke B F, Andreani D
出版信息
Clin Exp Immunol. 1986 Jul;65(1):57-65.
The possible correlation between soluble immune factors and platelet and coagulation factors has been evaluated in Type 1 diabetic patients with and without proliferative retinopathy, and in non-diabetic controls. Soluble immune complexes, platelet factor IV (PF4), beta-thromboglobulin, fibrinogen, factor VIII related antigen and anti-thrombin III were significantly increased in Type 1 diabetic patients with retinopathy as compared to non-diabetic controls. Fibrinogen and anti-thrombin III were also higher in those patients with retinopathy compared to those without retinopathy. A significant correlation was found between positive values of soluble immune complexes and increased levels of PF4 and beta-thromboglobulin in diabetic patients with retinopathy. The presence of soluble immune complexes and insulin-anti-insulin complexes was associated with a significantly greater number of elevated haemostatic factors in retinopathic patients. Our findings suggest that the interaction of platelets and soluble immune complexes or insulin-anti-insulin complexes may be pathologically relevant to the development of diabetic retinopathy.
在患有和未患有增殖性视网膜病变的1型糖尿病患者以及非糖尿病对照组中，对可溶性免疫因子与血小板及凝血因子之间可能存在的相关性进行了评估。与非糖尿病对照组相比，患有视网膜病变的1型糖尿病患者的可溶性免疫复合物、血小板第4因子（PF4）、β-血小板球蛋白、纤维蛋白原、因子VIII相关抗原和抗凝血酶III显著增加。与未患视网膜病变的患者相比，患有视网膜病变的患者的纤维蛋白原和抗凝血酶III也更高。在患有视网膜病变的糖尿病患者中，可溶性免疫复合物的阳性值与PF4和β-血小板球蛋白水平升高之间存在显著相关性。可溶性免疫复合物和胰岛素-抗胰岛素复合物的存在与视网膜病变患者中显著更多的止血因子升高有关。我们的研究结果表明，血小板与可溶性免疫复合物或胰岛素-抗胰岛素复合物之间的相互作用可能在糖尿病视网膜病变的发展中具有病理相关性。
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