Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China; Department of Physics, Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education and School of Physics and Technology, Wuhan University, Wuhan 430072, China.
Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China.
Biomaterials. 2018 May;164:11-21. doi: 10.1016/j.biomaterials.2018.02.040. Epub 2018 Feb 20.
In this paper, we propose a new shape memory polymer (SMP) composite with excellent near-infrared (NIR)-photoresponsive shape memory performance and biodegradability. The composite is fabricated by using piperazine-based polyurethane (PU) as thermo-responsive SMP incorporated with black-phosphorus (BP) sheets as NIR photothermal nanofillers. Under 808 nm light irradiation, the incorporated BP sheets with concentration of only 0.08 wt% enable rapid temperature increase over the glass temperature of PU and trigger the shape change of the composite with shape recovery rate of ∼100%. The in vitro and in vivo toxicity examinations demonstrate the good biocompatibility of the PU/BP composite, and it degrades naturally into non-toxic carbon dioxide and water from PU and non-toxic phosphate from BP. By implanting PU/BP columns into back subcutis and vagina of mice, they exhibit excellent shape memory activity to change their shape quickly under moderate 808 nm light irradiaiton. Such SMP composite enable the development of intelligent implantable devices, which can be easily controlled by the remote NIR light and degrade gradually after performing the designed functions in the body.
本文提出了一种具有优异近红外（NIR）光响应形状记忆性能和生物降解性的新型形状记忆聚合物（SMP）复合材料。该复合材料通过使用哌嗪基聚氨酯（PU）作为热敏 SMP，并掺入黑磷（BP）片作为 NIR 光热纳米填充剂来制备。在 808nm 光照射下，仅含有 0.08wt%浓度的掺入 BP 片能够使 PU 的玻璃化转变温度迅速升高，并触发复合材料的形状变化，形状回复率约为 100%。体外和体内毒性测试表明，PU/BP 复合材料具有良好的生物相容性，它会从 PU 中自然降解为无毒的二氧化碳和水，并从 BP 中降解为无毒的磷酸盐。将 PU/BP 柱植入小鼠背部皮下组织和阴道后，它们能够在适度的 808nm 光照射下快速改变形状，表现出出色的形状记忆活性。这种 SMP 复合材料能够开发出智能植入式设备，这些设备可以通过远程 NIR 光轻松控制，并在体内执行完设计功能后逐渐降解。
