Khan Talha Irfan, Sheh Zad Haris, Lazoglu Ismail, Yalcin Ozlem
Manufacturing and Automation Research Center, Koc University, Istanbul, 34450, Turkey.
School of Medicine, Koc University, Istanbul, Turkey.
J Artif Organs. 2018 Jun;21(2):142-149. doi: 10.1007/s10047-018-1028-3. Epub 2018 Feb 24.
The aim of this work was to analyze a shrouded impeller pediatric ventricular assist device (SIP-VAD). This device has distinctive design characteristics and parameter optimizations for minimization of recirculation flow and reduction in high-stress regions that cause blood damage. Computational Fluid Dynamics (CFD) simulations were performed to analyze the optimized design. The bench-top prototype of SIP-VAD was manufactured with biocompatible stainless steel. A study on the hydrodynamic and hemodynamic performance of the SIP-VAD was conducted with predictions from CFD and actual experimentation values, and these results were compared. The CFD analysis yielded a pressure range of 29-90 mmHg corresponding to flow rates of 0.5-3 L/min over 9000-11000 rpm. The predicted value of the normalized index of hemolysis (NIH) was 0.0048 g/100 L. The experimental results with the bench-top prototype showed a pressure rise of 30-105 mmHg for the flow speed of 8000-12000 rpm and flow rate of 0.5-3.5 L/min. The maximum difference between CFD and experimental results was 4 mmHg pressure. In addition, the blood test showed the average NIH level of 0.00674 g/100 L. The results show the feasibility of shrouded impeller design of axial-flow pump for manufacturing the prototype for further animal trials.
这项工作的目的是分析一种带 shrouded 叶轮的小儿心室辅助装置（SIP-VAD）。该装置具有独特的设计特点和参数优化，可将再循环流降至最低，并减少导致血液损伤的高应力区域。进行了计算流体动力学（CFD）模拟以分析优化后的设计。SIP-VAD 的台式原型采用生物相容性不锈钢制造。利用 CFD 的预测结果和实际实验值对 SIP-VAD 的流体动力学和血液动力学性能进行了研究，并对这些结果进行了比较。CFD 分析得出，在 9000 - 11000 转/分钟的转速下，对应于 0.5 - 3 升/分钟的流速，压力范围为 29 - 90 毫米汞柱。溶血归一化指数（NIH）的预测值为 0.0048 克/100 升。台式原型的实验结果表明，在 8000 - 12000 转/分钟的流速和 0.5 - 3.5 升/分钟的流量下，压力上升为 30 - 105 毫米汞柱。CFD 结果与实验结果之间的最大压力差为 4 毫米汞柱。此外，血液测试显示平均 NIH 水平为 0.00674 克/100 升。结果表明，轴流泵带 shrouded 叶轮的设计对于制造用于进一步动物试验的原型是可行的。
