The biosynthesis of prostaglandins in psoriatic skin.

The biosynthesis of prostaglandins (PGs) was studied in biopsy material taken from 8 psoriatics and 7 healthy controls. The psoriatic skin showed a statistically significant reduction in the capacity for PG synthesis: in psoriatic skin PGE2 was 301 +/- 74 ng/g wet weight and PGF2 alpha 425 +/- 89 ng/g wet weight, whereas in healthy skin the synthesizing capacity of PGE2 was 507 +/- 45 ng/g wet weight and of PGF2 alpha 730 +/- 206 ng/g wet weight.