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前列腺素的表皮合成及其对环磷酸腺苷水平的影响。

Epidermal synthesis of prostaglandins and their effect on levels of cyclic adenosine 3', 5'monophosphate.

作者信息

Aso K, Deneau D G, Krulig L, Wilkinson D I, Farber E M

出版信息

J Invest Dermatol. 1975 May;64(5):326-31. doi: 10.1111/1523-1747.ep12512267.

DOI:10.1111/1523-1747.ep12512267
PMID:167078
Abstract

Extracts of guinea-pig and human skin epidermis were analyzed for prostaglandins PGE1, E2, and F2alpha by radioimmunoassy, and found to contain a total of 62.0 (guinea pig) and 144.7 (human) ng/gm wet weight. the three prostaglandins occurred in approximately equal amounts. Guinea=pig epidermal homogenates converted labeled arachidonic acid to PGE2 and PGF2alpha, the rate of formaiton being 10 and 2.5 pmoles per mg protein in O.K hr, respectively. Conversion in the dermis occurred to a much smaller extent. Homogenates of univolved and involved epidermis from 10 subjects with psoriasis produced PGE2 from arachidonic acid at rates of 6.48 and 2...

摘要

通过放射免疫分析对豚鼠和人类皮肤表皮提取物中的前列腺素PGE1、E2和F2α进行了分析，发现其含量分别为每克湿重62.0（豚鼠）和144.7（人类）纳克。这三种前列腺素的含量大致相等。豚鼠表皮匀浆将标记的花生四烯酸转化为PGE2和PGF2α，在1小时内每毫克蛋白质的形成速率分别为10和2.5皮摩尔。真皮中的转化程度要小得多。对10名银屑病患者未受累和受累表皮的匀浆进行检测，发现其从花生四烯酸产生PGE2的速率分别为6.48和2...

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1
Epidermal synthesis of prostaglandins and their effect on levels of cyclic adenosine 3', 5'monophosphate.前列腺素的表皮合成及其对环磷酸腺苷水平的影响。
J Invest Dermatol. 1975 May;64(5):326-31. doi: 10.1111/1523-1747.ep12512267.
2
Effect of p-bromophenacyl bromide, an inhibitor of phospholipase A2, on arachidonic acid release and prostaglandin synthesis by the guinea-pig uterus in vitro.对溴苯甲酰溴（一种磷脂酶A2抑制剂）对豚鼠子宫体外花生四烯酸释放和前列腺素合成的影响。
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Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.银屑病表皮中非酯化花生四烯酸、12L-羟基-5,8,10,14-二十碳四烯酸、前列腺素E2和前列腺素F2α浓度升高。
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Synthesis of prostaglandins by psoriatic skin.银屑病皮肤中前列腺素的合成。
Arch Dermatol Res (1975). 1977 Sep 27;259(3):207-12. doi: 10.1007/BF00561448.
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Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa.影响豚鼠胃黏膜中花生四烯酸代谢的因素。
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引用本文的文献

1
Prostaglandin E1 in normal human skin: methodological evaluation, topographical distribution and data related to sex and age.正常人体皮肤中的前列腺素E1：方法学评估、分布情况以及与性别和年龄相关的数据
Arch Dermatol Res. 1983;275(1):9-13. doi: 10.1007/BF00516547.
2
Heat-separation of normal human skin for epidermal and dermal prostaglandin analysis.通过加热分离正常人皮肤以进行表皮和真皮前列腺素分析。
Arch Dermatol Res. 1982;273(3-4):301-6. doi: 10.1007/BF00409259.
3
Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.银屑病表皮中非酯化花生四烯酸、12L-羟基-5,8,10,14-二十碳四烯酸、前列腺素E2和前列腺素F2α浓度升高。
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5130-4. doi: 10.1073/pnas.72.12.5130.
4
Electron microscopic cytochemical demonstration of adenyl cyclase activity in psoriatic epidermis.银屑病表皮中腺苷酸环化酶活性的电子显微镜细胞化学显示
Arch Dermatol Res (1975). 1977 Apr 27;258(2):113-9. doi: 10.1007/BF00561615.
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Gastrointestinal cytoprotection by prostaglandins.前列腺素对胃肠道的细胞保护作用。
Gut. 1979 Jan;20(1):75-87. doi: 10.1136/gut.20.1.75.
6
Synthesis of prostaglandins by psoriatic skin.银屑病皮肤中前列腺素的合成。
Arch Dermatol Res (1975). 1977 Sep 27;259(3):207-12. doi: 10.1007/BF00561448.

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