Neurology Department, Mazandaran University of Medical Science, Booalisina Hospital, Pasdaran Boulevard, Sari, Iran.
Owens-gruppen Næstved/Slagelse/Ringsted Sygehuse, Region Sjælland J.B. Winsløws Vej 9, indgang B, 1. Sal 5000, Odense C, Denmark.
J Neurol Sci. 2018 May 15;388:222-231. doi: 10.1016/j.jns.2018.02.028. Epub 2018 Feb 19.
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system (CNS). Serum immunoglobulin G autoantibodies (NMO-IgG) are identified in the majority of NMOSD patients. The Pediatric form presents before 18 years. Based on the similarity of clinical, neuroimaging, and laboratory characteristics of pediatric NMOSD to those of the adult form, the international panel suggested that adult criteria of NMOSD also are appropriate in pediatric patients. However, the proposed criteria need validation in pediatric patients. This strategy poses challenges to the study design in clinical trials in pediatric NMOSD patients.
视神经脊髓炎谱系疾病（NMOSD）是一种中枢神经系统（CNS）自身免疫性炎症性疾病。大多数 NMOSD 患者的血清免疫球蛋白 G 自身抗体（NMO-IgG）可被识别。儿科形式出现在 18 岁之前。基于儿科 NMOSD 的临床、神经影像学和实验室特征与成人形式的相似性，国际小组建议成人 NMOSD 标准也适用于儿科患者。然而，这些拟议的标准需要在儿科患者中进行验证。在儿科 NMOSD 患者的临床试验中，这种策略给研究设计带来了挑战。
