Robinson Joan L
Canadian Paediatric Society, Infectious Diseases and Immunization Committee, Ottawa, Ontario.
Paediatr Child Health. 2018 Feb;23(1):e1-e4. doi: 10.1093/pch/pxx162. Epub 2018 Feb 15.
Invasive meningococcal disease (IMD) is serious, often resulting in fulminant sepsis or meningitis. IMD in Canada is primarily attributable to serogroups B and C. There are routine programs for serogroup C vaccine at 12 months of age, with some jurisdictions routinely providing additional earlier doses. Adolescents routinely receive a booster dose of serogroup C vaccine or of a quadrivalent (serogroups A, C, W and Y) vaccine. Serogroup B vaccines are not recommended for routine use pending further data on the efficacy and duration of protection from the available vaccine. However, children at increased risk for IMD should start immunization for serogroups B and C as soon as possible, assuming that they are at least 2 months of age.
侵袭性脑膜炎球菌病（IMD）病情严重，常导致暴发性败血症或脑膜炎。加拿大的IMD主要由B群和C群脑膜炎球菌引起。针对12月龄儿童有C群疫苗的常规接种计划，部分司法管辖区还常规提供额外的更早剂量接种。青少年常规接种一剂C群疫苗加强针或一剂四价（A、C、W和Y群）疫苗。在获得更多关于现有B群疫苗效力和保护持续时间的数据之前，不建议常规使用B群疫苗。然而，IMD风险增加的儿童，只要年满2月龄，应尽快开始接种B群和C群疫苗。
