Department of Dermatology, Zealand University Hospital, 4000 Roskilde, Denmark.
Department of Dermatology, Bispebjerg Hospital, 2400 Copenhagen, Denmark.
Contact Dermatitis. 2018 May;78(5):329-334. doi: 10.1111/cod.12964. Epub 2018 Feb 26.
Preventive skin care programmes have shown beneficial effects on the prevalence and severity of hand eczema, but most trials only report short-term outcomes. One such trial was the randomized Hand Eczema Trial (HET, 2009) investigating the effects of a secondary prevention programme in healthcare workers. Positive results have been reported at 5-month follow-up.
To examine the long-term (42-47 months) effects of the HET.
The present study was a follow-up questionnaire study on the effect of the intervention. Outcomes were the presence and severity of hand eczema, health-related quality of life (HR-QoL), skin protective behaviour, and knowledge of skin protection. A supplementary outcome was general improvement/worsening of hand eczema.
Comparison of the outcomes at follow-up showed no marked differences between the two groups. General improvement was reported by 70% in the intervention group and by 54% in the control group (p = 0.25). A small, statistically significant improvement was found regarding HR-QoL in the intervention group only (p = 0.015).
The impact of an intervention that is effective after 5 months is attenuated over time, with no long-term effect on the outcomes examined. We suggest that skin care education should be repeated at regular intervals.
预防性皮肤护理方案已显示对手部湿疹的患病率和严重程度有有益影响，但大多数试验仅报告短期结果。手部湿疹试验（HET，2009 年）是一项此类试验，该试验调查了医疗保健工作者二级预防方案的效果。在 5 个月的随访中报告了积极的结果。
研究 HET 的长期（42-47 个月）效果。
本研究是一项关于干预效果的随访问卷调查研究。结局为手部湿疹的存在和严重程度、与健康相关的生活质量（HR-QoL）、皮肤保护行为以及皮肤保护知识。补充结局为手部湿疹的总体改善/恶化。
与两组在随访时的结果比较，无明显差异。干预组有 70%报告有总体改善，对照组有 54%（p=0.25）。干预组仅在 HR-QoL 方面发现有较小但统计学上显著的改善（p=0.015）。
对 5 个月后有效的干预措施的影响随时间减弱，对所检查的结局没有长期影响。我们建议应定期重复进行皮肤护理教育。
