Teixidó Concepció, Díez Olga, Marsal Josep R, Giner-Soriano Maria, Pera Helena, Martinez Mireia, Galindo-Ortego Gisela, Schoenenberger Joan A, Real Jordi, Cruz Ines, Morros Rosa
Centre d'Atenció Primària Rambla Ferran, Institut Català de la Salut, Lleida, Spain.
Centro de Salud Casablanca, Zaragoza, Spain.
Pediatr Dermatol. 2018 May;35(3):336-342. doi: 10.1111/pde.13438. Epub 2018 Feb 26.
BACKGROUND/OBJECTIVES: Molluscum contagiosum is the most common skin infection in children. One topical treatment used for Molluscum contagiosum is potassium hydroxide. The objective of this study was to compare the efficacy of potassium hydroxide topical treatment at different concentrations with that of placebo in terms of complete clearing of Molluscum contagiosum lesions and to assess the safety and tolerance of potassium hydroxide topical treatment.
This was a double-blind randomized clinical trial of three treatments (potassium hydroxide 10%, potassium hydroxide 15%, placebo) applied once daily up to complete clearing of lesions (maximum duration 60 days) in 53 children aged 2-6 years in primary health care pediatric offices in Catalonia, Spain.
In the intention-to-treat analysis, potassium hydroxide 10% (58.8%, P = .03) and potassium hydroxide 15% (64.3%, P = .02) had efficacy superior to that of placebo (18.8%). The number of Molluscum contagiosum lesions was significantly reduced with potassium hydroxide 10% and 15%. The main efficacy outcome was achieved in 58.8% of children in the potassium hydroxide 10% group (P = .03 vs placebo) and in 64.3% of children in the potassium hydroxide 15% group (P = .02 vs placebo). Potassium hydroxide 10% and 15% were not significantly different in efficacy from each other. Potassium hydroxide 10% and placebo were better tolerated than potassium hydroxide 15%. No adverse events were reported during the study period.
Potassium hydroxide 10% and 15% demonstrated high rates of efficacy in clearing Molluscum contagiosum lesions, with potassium hydroxide 10% being better tolerated.
背景/目的：传染性软疣是儿童最常见的皮肤感染。用于治疗传染性软疣的一种局部治疗方法是氢氧化钾。本研究的目的是比较不同浓度氢氧化钾局部治疗与安慰剂在完全清除传染性软疣皮损方面的疗效，并评估氢氧化钾局部治疗的安全性和耐受性。
这是一项双盲随机临床试验，对西班牙加泰罗尼亚初级卫生保健儿科诊所的53名2至6岁儿童应用三种治疗方法（10%氢氧化钾、15%氢氧化钾、安慰剂），每日一次，直至皮损完全清除（最长持续时间60天）。
在意向性分析中，10%氢氧化钾组（58.8%，P = 0.03）和15%氢氧化钾组（64.3%，P = 0.02）的疗效优于安慰剂组（18.8%）。10%和15%氢氧化钾组的传染性软疣皮损数量显著减少。10%氢氧化钾组58.8%的儿童达到主要疗效结果（与安慰剂相比，P = 0.03），15%氢氧化钾组64.3%的儿童达到主要疗效结果（与安慰剂相比，P = 0.02）。10%氢氧化钾和15%氢氧化钾在疗效上无显著差异。10%氢氧化钾和安慰剂的耐受性优于15%氢氧化钾。研究期间未报告不良事件。
10%和15%氢氧化钾在清除传染性软疣皮损方面显示出高疗效，10%氢氧化钾的耐受性更好。
