Short Katherine A, Fuller L Claire, Higgins Elisabeth M
Department of Dermatology, King's College Hospital, Denmark Hill, London, United Kingdom.
Pediatr Dermatol. 2006 May-Jun;23(3):279-81. doi: 10.1111/j.1525-1470.2006.00235.x.
Molluscum contagiosum is a common viral infection of the skin that frequently affects children. Lesions take between 6 and 18 months to resolve spontaneously and are a source of great embarrassment to both caretakers and children, often affecting attendance at school and limiting social activity. Treatment options to date have been poorly tolerated by children but recent studies have suggested that potassium hydroxide may be beneficial. This double-blind, randomized, placebo-controlled study compared 10% potassium hydroxide with placebo (normal saline). Twenty patients, aged 2 to 12 years, were recruited. Parents applied a solution twice daily to lesional skin until signs of inflammation appeared. Children were examined by the same observer on days 0, 15, 30, 60, and 90. Seventy percent of children receiving topical potassium hydroxide cleared, compared with 20% in the placebo group. Further dosing studies are required to identify whether weaker concentrations of potassium hydroxide are as efficacious, with less irritancy.
传染性软疣是一种常见的皮肤病毒感染，常影响儿童。病变需6至18个月才能自行消退，这给照顾者和儿童都带来极大的困扰，常影响上学出勤率并限制社交活动。迄今为止，儿童对治疗方案的耐受性较差，但最近的研究表明氢氧化钾可能有益。这项双盲、随机、安慰剂对照研究将10%氢氧化钾与安慰剂（生理盐水）进行了比较。招募了20名年龄在2至12岁的患者。家长每天在皮损处涂抹溶液两次，直至出现炎症迹象。同一名观察者在第0、15、30、60和90天对儿童进行检查。接受局部氢氧化钾治疗的儿童中有70%症状消退，而安慰剂组为20%。需要进一步的剂量研究来确定浓度较低的氢氧化钾是否同样有效且刺激性更小。
