Schena F P, Pertosa G, Stanziale P, Germinario C, Balletta M, Andreucci V E
Nephron. 1986;44(4):272-6. doi: 10.1159/000184005.
Persistent activation of the complement system after escape from control by the regulatory proteins results in an excessive release of split products with inflammatory properties. Serum levels of the regulatory proteins of the complement system (Cl-INH, H, I and AT III) were assayed by the radial immunodiffusion technique in 521 serum samples from 124 patients with idiopathic chronic glomerulonephritis divided into two groups: 81 cases with normal renal function (NRF), and 43 cases with deteriorated renal function (DRF). Significant high mean levels of Cl-INH, H, I and AT III were found in patients with NRF, when they were compared with DRF patient groups. Positive correlations between the regulatory proteins and the corresponding complement components were found in patients with NRF, whereas they were reduced considerably in patients with DRF. Serial measurement of the control proteins showed a decay of the levels of Cl-INH, H and I in patients with progressive impairment of renal function. The presence of high levels of regulatory proteins suggest that a control mechanism may occur in patients with NRF; measurement of these proteins could, therefore, be of prognostic value, as the presence of high levels are indicative of a block of the complement system.
补体系统逃避调节蛋白的控制后持续激活，会导致具有炎症特性的裂解产物过度释放。采用放射免疫扩散技术，对124例特发性慢性肾小球肾炎患者的521份血清样本进行补体系统调节蛋白（C1抑制物、H因子、I因子和抗凝血酶III）血清水平检测，这些患者分为两组：81例肾功能正常（NRF）患者和43例肾功能恶化（DRF）患者。与DRF患者组相比，NRF患者中C1抑制物、H因子、I因子和抗凝血酶III的平均水平显著升高。NRF患者中调节蛋白与相应补体成分之间存在正相关，而DRF患者中这种相关性则显著降低。对调节蛋白进行连续测量显示，肾功能进行性损害患者中C1抑制物、H因子和I因子水平下降。高水平调节蛋白的存在表明NRF患者可能存在一种控制机制；因此，测量这些蛋白可能具有预后价值，因为高水平的存在表明补体系统受到阻滞。
