Stabile I, Nicolaides K H, Bach A, Teisner B, Rodeck C, Westergaard J G, Grudzinskas J G
Academic Unit of Obstetrics and Gynaecology, London Hospital Medical College, UK.
Br J Obstet Gynaecol. 1988 Mar;95(3):281-5. doi: 10.1111/j.1471-0528.1988.tb06870.x.
Complement factors (C3, C4, C5; Factors B, H and I) were measured in maternal and fetal serum and amniotic fluid obtained from 55 women with singleton pregnancy undergoing diagnostic fetoscopy at 15 to 28 weeks gestation. Maternal serum levels were consistently 10 times higher than fetal levels which in turn were 10 times higher than levels in amniotic fluid. Spearman rank correlation analysis at weeks 20 to 22 (n = 20) revealed a statistically significant correlation between maternal and fetal levels of C3 and Factors B and I, and between maternal and amniotic fluid levels of Factors B and I. A significant increase in fetal levels of C3, C4 and Factor H, and in amniotic fluid levels of C3 and Factor B was seen in relation to advancing gestational age. These differences were not seen in maternal serum during the short interval of pregnancy studied. These data confirm earlier assumptions of fetal synthesis of complement factors, and provide normal reference ranges of complement factors in fetal blood and amniotic fluid.
对55例孕15至28周接受诊断性胎儿镜检查的单胎妊娠女性的母血、胎儿血清和羊水进行补体因子（C3、C4、C5；B因子、H因子和I因子）检测。母血中补体因子水平始终比胎儿水平高10倍，而胎儿水平又比羊水中的水平高10倍。对孕20至22周（n = 20）的样本进行Spearman等级相关分析显示，母血与胎儿血中C3、B因子和I因子水平之间，以及母血与羊水中B因子和I因子水平之间存在统计学显著相关性。随着孕周增加，胎儿血中C3、C4和H因子水平以及羊水中C3和B因子水平显著升高。在所研究的较短孕期内，母血中未观察到这些差异。这些数据证实了先前关于胎儿合成补体因子的假设，并提供了胎儿血液和羊水中补体因子的正常参考范围。
