MacEwan Matthew R, MacEwan Sarah, Wright Anna P, Kovacs Tamas R, Batts Joel, Zhang Luke
Acera Surgical, Inc, St Louis, MO.
Telos Partners, LLC, Denver, CO.
Wounds. 2018 Feb;30(2):E21-E24.
This study aims to evaluate the comparative performance of a resorbable nanofiber wound matrix (Restrata Wound Matrix; Acera Surgical Inc, St Louis, MO) and a bilayered collagen xenograft (Integra Bilayer Matrix Wound Dressing; Integra, Plainsboro, NJ) in healing critical full-thickness cutaneous wounds in a preclinical porcine model.
Full-thickness cutaneous wounds were created in Yucatan miniature swine and treated with either the nanofiber wound matrix or xenograft. Wound area was measured and inflammation and healing were assessed until euthanasia at day 15 or 30, at which time tissue samples were harvested for histopathology.
Wounds treated with the nanofiber wound matrix demonstrated significantly faster wound areal reduction, less inflammation, greater neovascularization, more collagen maturation, and superior quality of healing compared with wounds treated with the xenograft.
The nanofiber wound matrix is an effective wound healing material that may offer a unique alternative in the treatment of challenging refractory wounds.
本研究旨在评估可吸收纳米纤维伤口基质（Restrata伤口基质；Acera Surgical公司，密苏里州圣路易斯）和双层胶原异种移植物（Integra双层基质伤口敷料；Integra，新泽西州普林斯顿）在临床前猪模型中愈合严重全层皮肤伤口方面的比较性能。
在尤卡坦小型猪身上制造全层皮肤伤口，并用纳米纤维伤口基质或异种移植物进行治疗。测量伤口面积，评估炎症和愈合情况，直至在第15天或第30天实施安乐死，此时采集组织样本进行组织病理学检查。
与用异种移植物治疗的伤口相比，用纳米纤维伤口基质治疗的伤口在伤口面积缩小方面明显更快，炎症更少，新生血管形成更多，胶原成熟度更高，愈合质量更好。
纳米纤维伤口基质是一种有效的伤口愈合材料，在治疗具有挑战性的难治性伤口方面可能提供一种独特的选择。
