Preparation of antimicrobial and hemostatic cotton with modified mesoporous particles for biomedical applications.

N-halamine polymers have been successfully attached surfaces of mesoporous materials. The modified mesoporous materials have been applied on the modification of cotton. Soaking in household bleach, the coated cotton shows good antimicrobial efficacy against S. aureus and E. coli O157:H7. The chlorinated samples could completely inactivate 100% S. aureus within 10 min, and 99.99% E. coli O157:H7 within 30 min. The chlorinated sample had better platelet adhesion and red blood cell cohesion than the control sample. The blood clotting index and fluid absorptive property of the samples enhanced after coating with modified mesoporous materials, indicating that the coated sample can prevent wound infection from bacteria and control hemorrhaging simultaneously. The coating of the modified mesoporous materials and N-halamines on cotton has not affect the bioactivity of cotton in the simulated body fluid. The active chlorine of the coated sample decreased 30% after soaking in the whole blood for 1 h. Considering the good antimicrobial efficacy against microorganisms and hemostasis property in blood control of the prepared materials, they have potentials for biomedical applications in wound dressing.