Key Laboratory of Eco-Textiles of Ministry of Education, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, PR China.
Key Laboratory of Eco-Textiles of Ministry of Education, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, PR China.
Colloids Surf B Biointerfaces. 2018 May 1;165:199-206. doi: 10.1016/j.colsurfb.2018.02.045. Epub 2018 Feb 20.
N-halamine polymers have been successfully attached surfaces of mesoporous materials. The modified mesoporous materials have been applied on the modification of cotton. Soaking in household bleach, the coated cotton shows good antimicrobial efficacy against S. aureus and E. coli O157:H7. The chlorinated samples could completely inactivate 100% S. aureus within 10 min, and 99.99% E. coli O157:H7 within 30 min. The chlorinated sample had better platelet adhesion and red blood cell cohesion than the control sample. The blood clotting index and fluid absorptive property of the samples enhanced after coating with modified mesoporous materials, indicating that the coated sample can prevent wound infection from bacteria and control hemorrhaging simultaneously. The coating of the modified mesoporous materials and N-halamines on cotton has not affect the bioactivity of cotton in the simulated body fluid. The active chlorine of the coated sample decreased 30% after soaking in the whole blood for 1 h. Considering the good antimicrobial efficacy against microorganisms and hemostasis property in blood control of the prepared materials, they have potentials for biomedical applications in wound dressing.
N-卤胺聚合物已成功附着在介孔材料的表面。改性介孔材料已应用于棉花的改性。将涂覆的棉花浸泡在家庭漂白剂中，对金黄色葡萄球菌和大肠杆菌 O157:H7 显示出良好的抗菌功效。氯化样品在 10 分钟内可完全灭活 100%的金黄色葡萄球菌，在 30 分钟内可完全灭活 99.99%的大肠杆菌 O157:H7。与对照样品相比，氯化样品的血小板粘附和红细胞凝聚性更好。用改性介孔材料涂覆后，样品的血栓形成指数和流体吸收性能增强，表明涂层样品可以防止细菌感染伤口并同时控制出血。改性介孔材料和 N-卤胺对棉花的涂层并未影响模拟体液中棉花的生物活性。浸泡在全血中 1 小时后，涂层样品的活性氯降低了 30%。考虑到制备材料对微生物的良好抗菌效果和对血液控制的止血性能，它们有可能在伤口敷料的生物医学应用中得到应用。
