Marakusha B I, Petrovskaia V G, Volkovoĭ K I
Zh Mikrobiol Epidemiol Immunobiol. 1986 Oct(10):3-8.
Mutants, resistant to neamine and spectinomycin, have been isolated from S. typhimurium and S. dublin highly virulent strains. The neamine-resistant mutants can be divided into 3 classes in accordance with their sensitivity to streptomycin: sensitive, resistant to low and high concentrations of this antibiotic. The transduction analysis with the use of bacteriophage P 22 has revealed that the spectinomycin-resistant mutations under study are spc A mutations, while the mutations leading to resistance to neamine in class Near Strr 500 are nea B mutations. The mutation leading to resistance to spectinomycin (spc A) has been found to produce no changes in the virulence of salmonellae in the intraperitoneal infection of mice. The mutations leading to resistance to neamine and streptomycin (nea B and str A) have been found to decrease virulence.
已从鼠伤寒沙门氏菌和都柏林沙门氏菌的高毒力菌株中分离出对新霉素和壮观霉素具有抗性的突变体。抗新霉素突变体可根据其对链霉素的敏感性分为3类：敏感型、对低浓度和高浓度这种抗生素具有抗性。使用噬菌体P 22进行的转导分析表明，所研究的抗壮观霉素突变是spc A突变，而导致Near Strr 500类对新霉素产生抗性的突变是nea B突变。已发现导致对壮观霉素产生抗性的突变（spc A）在小鼠腹腔感染中不会使沙门氏菌的毒力发生变化。已发现导致对新霉素和链霉素产生抗性的突变（nea B和str A）会降低毒力。
