Lu Lingyi, Lai Huiying, Pan Zhanyan, Hu Tingting, Hou Xiaoxiao, Cao Ke, Ju Qiang
Department of Dermatology, Ningbo First Hospital, Ningbo, Zhejiang, PR China.
Department of Dermatology, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China.
Dermatoendocrinol. 2017 Oct 4;9(1):e1361575. doi: 10.1080/19381980.2017.1361575. eCollection 2017.
: This study was designed to study the clinical and histopathological characteristics of patients with the scarring folliculitis type acne inversa in Chinese population. : A total of 21 patients with acne inversa and 6 controls without known dermatological disease were recruited from outpatient department of dermatology and orthopedic surgery. Two-millimeter punch biopsies were taken from 8 patients with acne inversa and 6 controls, fixed in formalin, embedded in paraffin and stained with haematoxylin and eosin prior to histopathological analysis. : There were 12 patients (57.14%) belonging to the scarring folliculitis type presented with double comedones, papules, nodules, depressed scars, and were mainly Hurley stage I (66.67%). Many of the scarring folliculitis type were smokers (58.33%), some had a history of occupational exposure (41.67%) and some were overweight (50%), the mean BMI of which is 25.18±3.16 kg/m. Histopathological changes such as perifollicular inflammation can be observed in scarring folliculitis type of acne inversa and controls as well. However, epidermal hyperplasia, follicular hyperplasia, sebaceous gland disappearance, destruction of hair follicle and sebaceous gland, collagen hyperplasia, perivascular inflammation, granulomatous inflammation, Micro thrombus were only seen in scarring folliculitis type. The mean surface area in patients (8073.36±15798.43 μm) was smaller than that in controls (302059.08±502813.78 μm), with statistically significant difference. (P = 0.024). : The scarring folliculitis type in acne inversa in Chinese population could be characterized by depressed scars, double-ended comedones, epidermal cysts and had high proportion of smokers, or occupational exposure with lower Hurley stage, as well as diminished sebaceous gland. Further studies are needed to clarify the relations between the clinical subtypes of acne inversa and their corresponding genetypes.
本研究旨在探讨中国人群中瘢痕性毛囊炎型反向性痤疮患者的临床及组织病理学特征。从皮肤科和整形外科门诊招募了21例反向性痤疮患者和6例无已知皮肤病的对照者。对8例反向性痤疮患者和6例对照者进行2毫米的打孔活检，固定于福尔马林中，石蜡包埋，苏木精-伊红染色后进行组织病理学分析。12例（57.14%）属于瘢痕性毛囊炎型，表现为双粉刺、丘疹、结节、凹陷性瘢痕，主要为Hurley I期（66.67%）。瘢痕性毛囊炎型患者中许多人吸烟（58.33%），一些人有职业暴露史（41.67%），一些人超重（50%），其平均体重指数为25.18±3.16kg/m。在瘢痕性毛囊炎型反向性痤疮和对照者中均可观察到毛囊周围炎症等组织病理学变化。然而，表皮增生、毛囊增生、皮脂腺消失、毛囊和皮脂腺破坏、胶原增生、血管周围炎症、肉芽肿性炎症、微血栓仅在瘢痕性毛囊炎型中可见。患者的平均表面积（8073.36±15798.43μm）小于对照者（302059.08±502813.78μm），差异有统计学意义（P = 0.024）。中国人群中反向性痤疮的瘢痕性毛囊炎型可表现为凹陷性瘢痕、双头粉刺、表皮囊肿，吸烟者或职业暴露者比例高，Hurley分期较低，皮脂腺减少。需要进一步研究以阐明反向性痤疮临床亚型与其相应基因型之间的关系。
