Wen Deng-Tai, Zheng Lan, Yang Fan, Li Han-Zhe, Hou Wen-Qi
Key Laboratory Of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Chang Sha, 410012, Hunan Province, China.
Oncotarget. 2017 Dec 15;9(7):7298-7311. doi: 10.18632/oncotarget.23292. eCollection 2018 Jan 26.
High-Fat-Diet (HFD)-induced obesity is a major contributor to heart and mobility premature aging and mortality in both and humans. The 2 genes are closely related to aging, but there are few directed reports showing that whether HFD could inhibit the expression 2 genes. Endurance exercise can prevent fat accumulation and reverse HFD-induced cardiac dysfunction. Endurance also delays age-relate functional decline. It is unclear whether lifetime endurance exercise can combat lifetime HFD-induced heart and mobility premature aging, and relieve the harmful HFD-induced influence on the 2 gene and lifespan yet. In this study, flies are fed a HFD and trained from when they are 1 week old until they are 5 weeks old. Then, triacylglycerol levels, climbing index, cardiac function, lifespan, and 2 mRNA expressions are measured. We show that endurance exercise improves climbing capacity, cardiac contraction, and 2 expression, and it reduces body and heart triacylglycerol levels, heart fibrillation, and mortality in both HFD and aging flies. So, lifelong endurance exercise delays HFD-induced accelerated age-related locomotor impairment, cardiac dysfunction, death, and 2 expression decline, and prevents HFD-induced premature aging in .
高脂饮食（HFD）诱导的肥胖是导致果蝇和人类心脏及运动功能过早衰老和死亡的主要因素。这两个基因与衰老密切相关，但很少有针对性的报告表明高脂饮食是否会抑制这两个基因的表达。耐力运动可以防止脂肪堆积并逆转高脂饮食诱导的心脏功能障碍。耐力运动还能延缓与年龄相关的功能衰退。目前尚不清楚终身耐力运动是否能够对抗终身高脂饮食诱导的心脏和运动功能过早衰老，并减轻高脂饮食对这两个基因和寿命的有害影响。在本研究中，果蝇从1周龄开始喂食高脂饮食并进行训练，直至5周龄。然后，测量三酰甘油水平、攀爬指数、心脏功能、寿命以及这两个基因的mRNA表达。我们发现，耐力运动可提高攀爬能力、心脏收缩能力以及这两个基因的表达，还能降低高脂饮食果蝇和衰老果蝇体内及心脏的三酰甘油水平、心脏颤动和死亡率。因此，终身耐力运动可延缓高脂饮食诱导的与年龄相关的运动功能加速衰退、心脏功能障碍、死亡以及这两个基因表达的下降，并防止高脂饮食诱导的果蝇过早衰老。
