Zhang Jinguo, Zhang Lingyun, Lin Qunbo, Ren Weimin, Xu Guoxiong
Center Laboratory, Jinshan Hospital, Fudan University, Shanghai 201508, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Oncotarget. 2017 Dec 21;9(7):7660-7671. doi: 10.18632/oncotarget.23546. eCollection 2018 Jan 26.
Endoglin (ENG, CD105), an auxiliary receptor for several TGF-β superfamily ligands, is constitutively expressed in tumor microvessels. The prognostic value of ENG-assessed microvessel density (MVD) has not been systemically analyzed. This meta-analysis reviews and evaluates the association between ENG expression and prognosis in cancer patients.
Thirty published studies involving in 3613 patients were included after searching of PubMed, Web of Science, and EMBASE. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) were calculated using random-effects models. The publication bias was detected by a Begg's test and Egger's test. The outcome stability was verified by sensitivity analysis.
The high ENG-assessed MVD was significantly associated with poor OS (HR = 2.14, 95% CI 1.62-2.81; < 0.001), DFS (HR = 3.23, 95% CI 2.10-4.95; < 0.001), CSS (HR = 3.33, 95% CI 1.32-8.37; < 0.001). Furthermore, subgroup analysis revealed that the association between the overexpression of ENG in tumor microvessels and the outcome endpoints (OS or DFS) were also significant in the Asians and Caucasians patients with different cancer types.
ENG of tumor microvessels is a predictor of poor OS, DFS and CSS and may be a prognostic marker of patients with cancer.
内皮糖蛋白（ENG，CD105）是几种转化生长因子-β超家族配体的辅助受体，在肿瘤微血管中组成性表达。ENG评估的微血管密度（MVD）的预后价值尚未得到系统分析。本荟萃分析回顾并评估了ENG表达与癌症患者预后之间的关联。
通过检索PubMed、Web of Science和EMBASE，纳入了30项涉及3613例患者的已发表研究。使用随机效应模型计算总生存期（OS）、无病生存期（DFS）和癌症特异性生存期（CSS）的合并风险比（HRs）和95%置信区间（CIs）。通过Begg检验和Egger检验检测发表偏倚。通过敏感性分析验证结果的稳定性。
ENG评估的高MVD与较差的OS（HR = 2.14，95% CI 1.62 - 2.81；< 0.001）、DFS（HR = 3.23，95% CI 2.10 - 4.95；< 0.001）、CSS（HR = 3.33，95% CI 1.32 - 8.37；< 0.001）显著相关。此外，亚组分析显示，在不同癌症类型的亚洲人和高加索人患者中，肿瘤微血管中ENG的过表达与结局终点（OS或DFS）之间的关联也很显著。
肿瘤微血管的ENG是OS、DFS和CSS较差的预测指标，可能是癌症患者的预后标志物。
