Hunninghake G W, Glazier A J, Monick M M, Dinarello C A
Am Rev Respir Dis. 1987 Jan;135(1):66-71. doi: 10.1164/arrd.1987.135.1.66.
Macrophages and T-lymphocytes physically interact in the lung in disorders such as sarcoidosis to initiate and/or maintain cellular immune responses. In these studies, we demonstrated that natural interleukin-1 (IL-1), as well as recombinant IL-1 beta, a polypeptide released from stimulated macrophages, is a potent chemotactic factor that is relatively specific for helper T-cells. This chemotactic activity is blocked by a species-specific anti-IL-1. Compared with its capacity to augment proliferation of phytohemagglutinin-stimulated murine thymocytes, IL-1 is more active as a chemotactic factor for mature T-cells. These studies suggest that stimulated lung macrophages, as well as other macrophages, may enhance their interaction with circulating T-lymphocytes via IL-1, which acts as both a chemoattractant and an initiator of T-lymphocyte activation.
在结节病等疾病中，巨噬细胞和T淋巴细胞在肺中发生物理相互作用，以启动和/或维持细胞免疫反应。在这些研究中，我们证明天然白细胞介素-1（IL-1）以及重组IL-1β（一种从受刺激的巨噬细胞释放的多肽）是一种有效的趋化因子，对辅助性T细胞具有相对特异性。这种趋化活性被种属特异性抗IL-1阻断。与其增强植物血凝素刺激的小鼠胸腺细胞增殖的能力相比，IL-1作为成熟T细胞的趋化因子更具活性。这些研究表明，受刺激的肺巨噬细胞以及其他巨噬细胞可能通过IL-1增强它们与循环T淋巴细胞的相互作用，IL-1既是一种趋化剂，也是T淋巴细胞激活的启动剂。
