缓解期螨抗原哮喘青少年白细胞介素-1分泌减少。
Reduced IL-1 production in adolescents with mite antigen asthma in remission.
作者信息
Noma T, Ichikawa K, Yoshizawa I, Aoki K, Kawano Y, Baba M
机构信息
Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
出版信息
Clin Exp Immunol. 1998 Jul;113(1):10-6. doi: 10.1046/j.1365-2249.1998.00619.x.
To determine the immunological mechanisms associated with outgrowing mite antigen-induced bronchial asthma during adolescence, we studied the relationship between clinical status and Dermatophagoides farinae (Df) antigen-induced peripheral cell activation by measuring IL-1alpha and IL-1beta production in patients with bronchial asthma. After antigen-driven restimulation in vitro, there was increased IL-1alpha, IL-1beta production by peripheral blood mononuclear cells (PBMC) from patients with active bronchial asthma, while cellular IL-1alpha, IL-1beta production was reduced in patients with asthma in remission. IL-1alpha and IL-1beta production by PBMC (possibly reflecting airway inflammation) after exposure to Df antigen might be down-regulated in patients outgrowing mite antigen-induced asthma, because lipopolysaccharide-induced IL-1alpha, IL-1beta production (seen in both normal individuals and patients with active asthma) was also reduced when patients were in remission.
为了确定青春期摆脱螨抗原诱导的支气管哮喘所涉及的免疫机制，我们通过测量支气管哮喘患者白细胞介素-1α（IL-1α）和白细胞介素-1β（IL-1β）的产生，研究了临床状态与粉尘螨（Df）抗原诱导的外周细胞活化之间的关系。在体外抗原驱动的再刺激后，活动性支气管哮喘患者外周血单核细胞（PBMC）产生的IL-1α和IL-1β增加，而缓解期哮喘患者细胞IL-1α和IL-1β的产生减少。摆脱螨抗原诱导哮喘的患者，暴露于Df抗原后PBMC产生的IL-1α和IL-1β（可能反映气道炎症）可能下调，因为当患者处于缓解期时，脂多糖诱导的IL-1α和IL-1β产生（在正常人和活动性哮喘患者中均可见）也减少。
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