Division of Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Division of Endocrinology, Department of Internal Medicine, Endocrine Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.
Nutrients. 2021 May 11;13(5):1598. doi: 10.3390/nu13051598.
This study assessed the association between serum vitamin E levels and hand grip strength (HGS) in community-dwelling adults data of 1011 men aged 50 years and older and 1144 postmenopausal women were analyzed. Low HGS was defined as HGS below the sex-stratified median value. Proportion of low HGS was the greatest in the lowest quintile of serum vitamin E level (<10.51 mg/L, 57.1%), with a decreasing trend toward the highest vitamin E quintile (>17.81 mg/L, 43.6%; < 0.001). A one-unit (mg/L) decrease in vitamin E levels was associated with lower HGS in men (adjusted beta coefficient -0.10, 95% confidence interval [CI] -0.18 to -0.02, = 0.019), but not in women (-0.01, 95% CI -0.06 to 0.03, = 0.550). Compared with the middle quintile (Q3; 12.59-14.69 mg/L), the lowest vitamin E quintile (Q1) was associated with elevated odds of low HGS (adjusted odds ratio [aOR]: 1.38, = 0.045), independent of sociodemographic factors, health-related lifestyles, comorbidities, dietary intake, and cholesterol level. However, the odds of low HGS did not differ significantly in other vitamin E quintiles (Q2, aOR 1.12; Q4, aOR 1.38; Q5, aOR 1.12; > 0.05). Individuals with the lowest quintile vitamin E level had elevated odds of low HGS independent of covariates, findings which merit further validation.
本研究评估了血清维生素 E 水平与社区居住的成年人握力（HGS）之间的关联。分析了 1011 名 50 岁及以上男性和 1144 名绝经后女性的数据。低 HGS 定义为 HGS 低于性别分层中位数。血清维生素 E 水平最低五分位数（<10.51mg/L，57.1%）的低 HGS 比例最高，呈向最高维生素 E 五分位数（>17.81mg/L，43.6%）递减趋势（<0.001）。维生素 E 水平降低一个单位（mg/L）与男性 HGS 降低相关（调整后的β系数-0.10，95%置信区间[CI]-0.18 至-0.02， = 0.019），但与女性无关（-0.01，95%CI-0.06 至 0.03， = 0.550）。与中间五分位数（Q3；12.59-14.69mg/L）相比，最低维生素 E 五分位数（Q1）与 HGS 降低的比值比（aOR）升高相关（调整后的比值比[aOR]：1.38， = 0.045），独立于社会人口统计学因素、与健康相关的生活方式、合并症、饮食摄入和胆固醇水平。然而，其他维生素 E 五分位数（Q2，aOR 1.12；Q4，aOR 1.38；Q5，aOR 1.12）的低 HGS 比值比无显著差异（>0.05）。在调整了协变量后，血清维生素 E 水平最低五分位数的个体低 HGS 比值比升高，这一发现值得进一步验证。
