使用Bio-Oss和胶原膜修复大鼠颅骨缺损的新骨形成过程：组织学观察

New Bone Formation Process Using Bio-Oss and Collagen Membrane for Rat Calvarial Bone Defect: Histological Observation.

作者信息

Kasuya Shin, Kato-Kogoe Nahoko, Omori Michi, Yamamoto Kayoko, Taguchi Shogo, Fujita Hiroshi, Imagawa Naoko, Sunano Akihiro, Inoue Kazuya, Ito Yuichi, Hirata Azumi, Ueno Takaaki, Moy Peter K

机构信息

Fellow, Department of Dentistry and Oral Surgery, Division of Medicine for Function and Morphology of Sensor Organs, Faculty of Medicine, Osaka Medical College, Takatsuki, Japan.

Assistant Professor, Department of Dentistry and Oral Surgery, Division of Medicine for Function and Morphology of Sensor Organs, Faculty of Medicine, Osaka Medical College, Takatsuki, Japan.

出版信息

Implant Dent. 2018 Apr;27(2):158-164. doi: 10.1097/ID.0000000000000738.

DOI:10.1097/ID.0000000000000738

PMID:29485462

Abstract

PURPOSE

We carried out guided bone regeneration of cranial bone defects in rats using the bovine bone substitute Bio-Oss and a collagen membrane and performed histological observations of the bone repair process.

MATERIALS AND METHODS

Bone defects were created in the cranial bones of 30 15-week-old Sprague-Dawley rats. We made 3 groups. A is unfilled, B is Bio-Oss, and C is Bio-Oss plus a collagen membrane. At 4 or 8 weeks postoperatively, tissue samples were taken. The Kawamoto technique was used for histological evaluation.

RESULTS

There was no new bone formation in group A. In groups B and C, new bone formation was evident around the Bio-Oss. In group C, new bone formation was evident in the centers of the bone defects, detached from the cut edge of the cranial bone.

CONCLUSION

Our results suggested that the Bio-Oss acts as a scaffold for bone repair, and the use of a collagen membrane may anchor the Bio-Oss closely to the cranial bone and assist the bone repair response.

摘要