Inan Muzaffer, Salturk Ziya, Ayaz Gizem, Ozdemir Erdi, Kumral Tolgar Lutfi, Berkiten Guler, Tutar Belgin, Sari Hüseyin, Uyar Yavuz
Suleymaniye Obstetric and Gynecology Hospital ENT Department.
Okmeydani Training and Research Hospital ENT Clinic.
J Craniofac Surg. 2018 May;29(3):e322-e325. doi: 10.1097/SCS.0000000000004400.
To investigate effects of smoking cigarette on male and female larynges and compare them.
Eighteen adult Wistar Albino rats were included to study; 9 were male and 9 female. The exposure groups each contained 6 rats, and the control groups 3 rats. Six male constituted group 1 and 6 female constituted group 2. Group 1 and 3 were exposed to smoke. Group 2 and 4 were composed of 3 males and 3 females, respectively. Smoke from 10 cigarettes was delivered in each of the morning and afternoon daily for 1 month. At the end of 4 weeks, all rats were sacrificed and their larynges were evaluated histopathologically.
Microscobic evaluation of epithelium of vocal folds revealed no significant difference between study groups. There was also no difference between study and control groups. Subepitelial tissue showed no difference between study groups but angiogenesis and inflammation were higher in study groups. Epithelial analysis of false vocal folds showed significant difference between study groups. Female epithelium showed more hyperplastic and metaplastic changes.
Cigarette smoke damaged both the vocal folds and false vocal folds. The female false vocal folds were more susceptible to damage than the males.
研究吸烟对雄性和雌性大鼠喉部的影响并进行比较。
纳入18只成年Wistar白化大鼠进行研究；其中9只为雄性，9只为雌性。暴露组每组6只大鼠，对照组每组3只大鼠。6只雄性大鼠构成第1组，6只雌性大鼠构成第2组。第1组和第3组暴露于烟雾中。第2组和第4组分别由3只雄性和3只雌性大鼠组成。每天上午和下午各吸入10支香烟的烟雾，持续1个月。4周结束时，处死所有大鼠，对其喉部进行组织病理学评估。
声带上皮的显微镜评估显示研究组之间无显著差异。研究组与对照组之间也无差异。上皮下组织在研究组之间无差异，但研究组的血管生成和炎症更高。假声带的上皮分析显示研究组之间存在显著差异。雌性上皮显示出更多的增生和化生变化。
香烟烟雾对声带和假声带均有损害。雌性假声带比雄性更易受损。
