急性耐力运动在体重增加的早期增加了大鼠脂肪组织中 Vegfa mRNA 的表达。
Acute endurance exercise increases Vegfa mRNA expression in adipose tissue of rats during the early stages of weight gain.
机构信息
School of Kinesiology, University of Michigan, 401 Washtenaw Ave., Ann Arbor, MI 48109, USA.
出版信息
Appl Physiol Nutr Metab. 2018 Jul;43(7):751-754. doi: 10.1139/apnm-2017-0434. Epub 2018 Feb 27.
Abstract
The aim of this study was to determine the effects of acute exercise on key factors regulating angiogenesis in adipose tissue. Adipose tissue Vegf-a messenger RNA expression was upregulated immediately after acute exercise (p < 0.05) in rats consuming a high-fat diet, but was lower after exercise (p < 0.05) in rats consuming a low-fat diet. Our working hypothesis is that acute exercise augments angiogenic signaling under conditions when adipose tissue is expanding, and with repeated exercise sessions these signals can accrue to enhance vascularization.
摘要
本研究旨在确定急性运动对调节脂肪组织血管生成的关键因素的影响。高脂肪饮食的大鼠在急性运动后（p<0.05），脂肪组织 Vegf-a 信使 RNA 表达即刻上调，但低脂饮食的大鼠在运动后（p<0.05）表达降低。我们的工作假设是，在脂肪组织扩张时，急性运动增强血管生成信号，并且随着重复运动，这些信号可以积累以增强血管化。
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Sci Rep. 2017 Oct 20;7(1):13642. doi: 10.1038/s41598-017-12682-z.
2
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3
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Mol Metab. 2016 Sep 9;5(11):1113-1120. doi: 10.1016/j.molmet.2016.09.001. eCollection 2016 Nov.
4
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