Bang Young Rong, Jeon Hong Jun, Park Hye Youn, Yoon In-Young
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Psychiatry, Konkuk University Medical Center, Seoul, Republic of Korea.
Psychiatry Investig. 2018 Apr;15(4):390-395. doi: 10.30773/pi.2017.08.21. Epub 2018 Feb 28.
The aim of this study was to determine the clinical course of restless legs syndrome (RLS) and potential risk factors for the persistence of RLS symptoms after iron normalization in women with RLS and low serum ferritin (<50 μg/L).
We reviewed 39 women with RLS and iron deficiency, who achieved iron normalization after oral iron replacement for three months. Risk factors contributing to symptom persistence were estimated by logistic regression analyses. Remission was defined as no RLS symptoms for at least 6 months after the iron normalization.
Over the observation period of 2.5±1.4 years, 15 patients reported no RLS symptom whereas 24 patients still complained of RLS symptoms. The remission rate of RLS with iron replacement was 38.5%. The relative risk of symptom persistence was increased by the duration of RLS symptoms (OR: 1.88, 95% CI: 1.01-3.49) or by the age at RLS diagnosis (OR: 1.25, 95% CI: 1.01-1.56).
Almost two-third of RLS patients with iron deficiency showed persistence of the symptom even after iron normalization. Considering that longer duration of RLS symptoms and older age at RLS diagnosis were risk factors for symptom persistence, early intervention of iron deficiency in RLS is warranted.
本研究旨在确定不安腿综合征（RLS）的临床病程，以及血清铁蛋白水平低（<50μg/L）的RLS女性患者铁水平恢复正常后RLS症状持续存在的潜在风险因素。
我们回顾了39例患有RLS和缺铁的女性患者，她们在口服铁剂替代治疗三个月后铁水平恢复正常。通过逻辑回归分析评估导致症状持续的风险因素。缓解定义为铁水平恢复正常后至少6个月无RLS症状。
在2.5±1.4年的观察期内，15例患者报告无RLS症状，而24例患者仍抱怨有RLS症状。铁剂替代治疗后RLS的缓解率为38.5%。RLS症状持续时间（OR：1.88，95%CI：1.01-3.49）或RLS诊断时的年龄（OR：1.25，95%CI：1.01-1.56）增加了症状持续的相对风险。
几乎三分之二的缺铁性RLS患者即使在铁水平恢复正常后仍有症状持续。考虑到RLS症状持续时间较长和RLS诊断时年龄较大是症状持续的风险因素，对RLS患者的缺铁进行早期干预是必要的。
