von Allmen Daniel
Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Clin Colon Rectal Surg. 2018 Mar;31(2):80-88. doi: 10.1055/s-0037-1609022. Epub 2018 Feb 25.
The incidence of Crohn's disease in the pediatric population is increasing. While pediatric patients with Crohn's disease exhibit many of the characteristics of older patients, there are important differences in the clinical presentation and course of disease that can impact the clinical decisions made during treatment. The majority of children are diagnosed in the early teen years, but subgroups of very early onset and infantile Crohn's present much earlier and have a unique clinical course. Treatment paradigms follow the traditional laddered approach, but growth and development represent special considerations that must be given to pediatric-specific complications of the treatment and disease. Surgical intervention is an important component of Crohn's management and is often employed to allow improved nutritional intake or decrease reliance on medical treatments that compromise growth.
儿童人群中克罗恩病的发病率正在上升。虽然患有克罗恩病的儿科患者表现出许多成年患者的特征,但在临床表现和疾病进程方面存在重要差异,这些差异会影响治疗期间做出的临床决策。大多数儿童在青少年早期被诊断出,但极早发和婴儿型克罗恩病亚组发病要早得多,且有独特的临床病程。治疗模式遵循传统的阶梯式方法,但生长发育是特殊考虑因素,必须考虑到治疗和疾病的儿科特定并发症。手术干预是克罗恩病治疗的重要组成部分,常被用于改善营养摄入或减少对影响生长的药物治疗的依赖。